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FLASH GENE
Symbol UGP2 contributors: mct - updated : 20-11-2018
HGNC name UDP-glucose pyrophosphorylase 2
HGNC id 12527
Location 2p15      Physical location : 64.068.097 - 64.118.695
Synonym name
  • UTP-glucose 1 phosphate uridyltransferase
  • uridyl diphosphate glucose pyrophosphorylase 2
  • Synonym symbol(s) UGPP2, UDPGP2, UDPG
    EC.number 2.7.7.9
    DNA
    TYPE functioning gene
    STRUCTURE 50.60 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    XPO1 2p16 exportin 1 (CRM1 homolog, yeast) LOC391376 2 similar to 60S ribosomal protein L14 (CAG-ISL 7) FLJ13305 2p15 hypothetical protein FLJ13305 CCT4 2p13.3 chaperonin containing TCP1, subunit 4 (delta) C2orf5 2p15 chromosome 2 open reading frame 5 (MURR1) LOC388954 2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) B3GNT1 2p14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 FLJ34583 KIAA0903 2p15 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a HSPC159 2p15 HSPC159 protein FLJ20080 2p15 hypothetical protein FLJ20080 TRIP-Br2 2p15 transcriptional regulator interacting with the PHS-bromodomain 2 SLC1A4 2p13.3 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 LOC200731 2p14 hypothetical LOC200731 KIAA0582 2p14 hypothetical LOC200731 RAB1A 2p14 RAB1A, member RAS oncogene family LOC150984 2p14 similar to voltage-dependent anion channel isoform 2 ACTR2 2p14 ARP2 actin-related protein 2 homolog (yeast) SPRED2 2p14 sprouty-related, EVH1 domain containing 2 LOC388956 2 LOC388956 LOC391379 2 similar to DnaJ homolog subfamily B member 12 LOC391380 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2185 - 508 - 2012 22132858
    10 - 2129 - 497 - 2012 22132858
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     intestine   highly
     liver   highly
    Endocrineparathyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , hexamer
    HOMOLOGY
    Homologene
    FAMILY eukaryotic UDPGP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION playing a central role as a glucosyl donor in cellular metabolic pathways
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    hypoxia that upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1), two enzymes involved in the biosynthesis of glycogen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
  • positive PTPN11 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer
  • Therapy target
    ANIMAL & CELL MODELS