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FLASH GENE
Symbol UGCG contributors: - updated : 24-03-2007
HGNC name UDP-glucose ceramide glucosyltransferase
HGNC id 12524
Location 9q31      Physical location : 114.659.205 - 114.695.431
Synonym name
  • ceramide glucosyltransferase
  • glucosylceramide synthase
  • Synonym symbol(s) GCS
    EC.number 2.4.1.80
    DNA
    TYPE functioning gene
    STRUCTURE 36.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked   status provisional
    Physical map
    MUSK 9q31.3-q32 muscle, skeletal, receptor tyrosine kinase EDG2 9q31.3-q32 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 OR2K2 9q32 olfactory receptor, family 2, subfamily K, member 2 OR2AR1P 3p24.1 olfactory receptor, family 2, subfamily AR, member 1 pseudogene KIAA0368 9q22.3-q32 olfactory receptor, family 2, subfamily AR, member 1 pseudogene ZNF483 9 zinc finger protein 483 LTB4DH 9q32 leukotriene B4 12-hydroxydehydrogenase LOC392383 9 similar to hypothetical protein FLJ10120 GNG10 9q31-q32 guanine nucleotide binding protein (G protein), gamma 10 FLJ32779 UGCG 9q31 UDP-glucose ceramide glucosyltransferase DKFZP761E1824 ROD1 9q32 ROD1 regulator of differentiation 1 (S. pombe) EPF5 9q33.1 EPF5 pseudogene LOC392384 9 similar to 60S ribosomal protein L32 MGC10940 9q33.1 hypothetical protein MGC10940 LOC389784 9 LOC389784 KIAA1958 9q33.1 KIAA1958 HSPC043 LOC389785 9 similar to RIKEN cDNA 4732481H14 LOC169831 9q33.1 similar to RIKEN cDNA 4732481H14 TSCOT 6p21-p11.2 thymic stromal co-transporter LOC169834 9q33.1 hypothetical protein LOC169834 ZFP37 9q32 zinc finger protein 37 homolog (mouse) SLC31A2 9q31-q32 solute carrier family 31 (copper transporters), member 2 SLC31A1 9q31-q32 solute carrier family 31 (copper transporters), member 1 CDC26 9q32 cell division cycle 26 PRPF4 9q31-q33 PRP4 pre-mRNA processing factor 4 homolog (yeast) MGC4734 9q33.1 hypothetical protein MGC4734 WDR31 9q33.1 WD repeat domain 31 BSPRY 9q33.1 B-box and SPRY domain containing
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • catalyzing the first glycosylation step of glycosphingolipid synthesis
  • key enzyme in the biosynthesis of glycosphingolipids, has been implicated in many biological phenomena, including multidrug resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein RTN1C major UGCG partner (regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    at the transcriptional level during keratinocyte differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS