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FLASH GENE
Symbol UFL1 contributors: mct/pgu - updated : 12/12/2008
HGNC name UFM1-specific ligase 1
HGNC id 23039
Location 6q16.1      Physical location : -
Genatlas name novel LZAP-binding protein
Synonym name
  • hypothetical protein LOC23376
  • E3 UFM1-protein ligase 1
  • KIAA0776
  • Regulator of C53/LZAP and DDRGK1
  • Synonym symbol(s) RP3-393D12.1, KIAA0776, NLBP, Maxer, RCAD
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 33.45 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4219 89.4 794 - 2010 20018847
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas   highly Homo sapiens
     pancreas    
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UFL1 family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may act as a novel tumor suppressor by inhibiting cell invasion, blocking NF-kappaB signaling, and increasing stability of the LZAP protein
  • E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116
  • UFL1, like CDK5RAP3, also plays an important role in regulation of NF-kappaB signaling and cell invasion
  • is a novel regulator of CDK5RAP3 tumor suppressor and NF-kappaB signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)
  • CDK5RAP3 and UFL1 may form a large protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DDRGK1/C20orf116 and UFC1
  • interacting with CDK5RAP3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS