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FLASH GENE
Symbol UFC1 contributors: mct - updated : 24-09-2011
HGNC name ubiquitin-fold modifier conjugating enzyme 1
HGNC id 26941
Location 1q23.3      Physical location : 161.123.533 - 161.128.645
Synonym name Ufm1-conjugating enzyme 1
Synonym symbol(s) CGI-126, HSPC155
DNA
TYPE functioning gene
STRUCTURE 5.11 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1124 21 167 - 2009 19101823
EXPRESSION
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a canonical E2 domain and an additional N-terminal domain (N-terminal unique domain of Ufc1 contributes to thermal stability)
  • a UBA5 binding site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • play central roles in posttranslational modification processes
  • involved in the transfer of ubiquitin-fold modifier 1 (UFM1), a ubiquitin like protein which is activated by E1-like enzyme UBA5, to various target proteins
  • participates in the very recently discovered UFM1-UBA5-UFC1 ubiquination pathway
  • is one of the enzymes involved in modification of proteins with the ubiquitin-like molecule ubiquitin-fold modifier-1 (UFM1)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UFM1-UBA5-UFC1 ubiquination pathway
    a component
  • fusion protein between UBA5 381-404 and UFC1 exists as a homodimer in solution
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UFM1-conjugating enzyme
  • UFM1 covalently attach with cellular protein(s) via a specific E1-activating enzyme (UBA5) and an E2-conjugating enzyme (UFC1)
  • UFC1 is an interaction partner of NCAM140
  • Ufmylation is initiated by UBA5, which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS