| basic FUNCTION
| implicated in bioenergetics and reactive oxygen species (ROS) modulation |
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dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion |
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H+ transporter, fatty acid dependent inhibited by low concentration of nucleotides |
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negative regulator of insulin secretion (beta cells dysfunction) |
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involved in the thermogenesis and variation of energy metabolism with a reduced expression in skeletal muscle and intraperitoneal tissue and in obesity |
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may be protecting cardiomyocytes from oxidative stress-induced cell death by reducing reactive oxygen species (ROS) production in mitochondria |
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may represent an effective weaponry used by germ cells to combat radical oxygen species -induced apoptosis, protecting testicular germ cells from hyperthermia-induced apoptosis |
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mitochondrial protein that impairs glucose-stimulated ATP production and negatively regulates glucose sensing in POMC neurons |
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UCP2-mediated loss of glucose sensing in glucose-excited neurons could be an important pathogenic component of type 2 diabetes |
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negative regulator of insulin secretion in beta-cells and negatively regulates glucose sensing in POMC neurons |
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playing a role in autoimmune diabetes |
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regulator of erythropoiesis and inhibition of UCP2 function may contribute to the development of anemia |
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has a role early in erythropoiesis, specifically during the EPO-dependent phase, where it likely controls the amount of ROS available for the activation of MAPK/ERK pathway and, thus, modulates cell proliferation and maturation |
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being essential for mitochondrial Ca(2+) uptake |
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accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages  |
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its activity contributes to beta cell pathogenesis and development of type 2 diabetes |
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transcriptional upregulation of UCP2 in response to oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons that maintain vasomotor tone located |
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mitochondrial protein that inhibits insulin secretion from beta cells, possibly through down-regulation of reactive oxygen species production |
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can potentially regulate mast cell activation |
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plays an important role in fat metabolism by promoting fat oxidation and restricts ghrelin-induced lipogenesis |
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modulates myocardial excitation-contraction coupling |
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determinant of fat oxidation pathways that may be involved in the changes seen in the metabolic pathways in thyroid disease |
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UCP2/UCP3 are essential for mitochondrial Ca(2+) uptake but both proteins exhibit distinct activities in regard to the source and mode of Ca(2+) mobilization |
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UCP2 expression increased significantly with follicular development in both control and Polycystic ovary syndrome (PCOS) tissue, with expression in early stage follicles from PCOS patients significantly greater than that in controls |
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UCP2/3 are fundamental for mitochondrial uptake of high Ca2+ domains in mitochondria-ER junctions |
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LETM1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca2+ uptake pathways in intact endothelial cells |
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UCP2 and UCP3 have been postulated to catalyze Ca(2+) entry across the inner membrane of mitochondria |
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may contribute to the regulation of hypoglycemia-induced GCG secretion, which is supported by our current finding that UCP2 expression is increased in nutrient-deprived human islets |
