Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UCN3 contributors: SGE/npt - updated : 19-03-2010
HGNC name urocortin 3 (stresscopin)
HGNC id 17781
Location 10p15.1      Physical location : 5.406.975 - 5.416.169
Synonym name stresscopin
Synonym symbol(s) SCP, SPC, UCNIII, MGC119002
DNA
TYPE functioning gene
STRUCTURE 9.19 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 710 - 161 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineadrenal gland    
 neuroendocrinepituitary   
Nervousbrain    
Reproductivefemale systemplacenta    Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell
Reproductivelutein cell
cell lineage
cell lines
fluid/secretion plasma, urine, follicular fluid
at STAGE
physiological period pregnancy
Text cytotrophoblast and syncytiotrophoblast cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide for secretion
  • the predicted mature region flanked by potential proteolytic cleavage sites
  • an alpha-amidation donor residue
  • HOMOLOGY
    Homologene
    FAMILY
  • sauvagine/corticotropin-releasing factor/urotensin I family
  • corticotrophin-releasing hormone (CRH) family of peptides
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be representing endogenous ligand for maintaining homeostasis after stress
  • in the brain, may be responsible for the effects of stress on appetite
  • suppresses food intake, delays gastric emptying and decreases heart-induced edema
  • may inhibit progesterone production through interaction with CRHR2 (Yata 2009)
  • may act as an autocrine or paracrine regulator in normal adrenal and adrenal tumors (Takahashi 2006)
  • playing some physiological or pathologic roles in the modulation of gastro intestinal functions during stressful conditions (Saruta 2005)
  • novel role for UCN3 and CRHR2 related to the processing of social cues and to the establishment of social memories
  • may regulate the cardiac and renal functions as a local factor and a circulating hormone (Takahashi 2004)
  • possible involvement of UCN2 and UCN3 in the mechanisms of endometriosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in preeclamptic (PE) placentae, the increased expression of UCN2, UCN3 may reflect a response to the oxidative stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS