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FLASH GENE
Symbol UCN2 contributors: mct - updated : 20-03-2014
HGNC name urocortin 2
HGNC id 18414
Location 3p21.31      Physical location : 48.599.150 - 48.601.201
Synonym name
  • stresscopin
  • stresscopin-related peptide
  • urocortin II
  • urocortin-related peptide
  • Synonym symbol(s) SRP, URP, UCNI, UCN-II, UR
    DNA
    TYPE functioning gene
    STRUCTURE 2.05 kb     2 Exon(s)
    regulatory sequence Binding site   HRE
    text structure a specific hypoxia-responsive element in the 3' flanking region of UCN2 gene, which interacts with the transcription factor HIF1 alpha (Bühler 2009)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1546 12 112 - 2001 11329063
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Nervousbrain    
    Reproductivefemale systemplacenta  highly Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothuterusmyometrium 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    reproductiveuterus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text maternal and fetal vessels, and in amniotic cells (Imperatore 2006)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide for secretion
  • the region containing the 43-amino acid mature peptide is flanked by potential proteolytic cleavage sites and an alpha-amidation donor residue
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Urp
    Homologene
    FAMILY
  • sauvagine/corticotropin-releasing factor/urotensin I family
  • corticotropin-releasing factor (CRF) family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text expressed in endometrium, highly in the early proliferative phase of the menstrual cycle (Florio 2006)
    basic FUNCTION
  • endogenous ligands for maintaining homeostasis after stress, and could allow the design of drugs to ameliorate stress-related diseases
  • involved in the control of myometrial contractility during pregnancy
  • in the brain it may be responsible for the effects of stress on appetite
  • might represent an endogenous ligand for maintaining homeostasis after stress
  • exert an anti-inflammatory effect via induction of macrophage apoptosis (through CRHR2 binding)
  • can suppress tumor growth predominantly by inhibition of tumor vascularization, but also potentially through direct effects on tumor cell proliferation
  • exerts potent beneficial effects in the cardiovascular system, including inhibition of apoptosis, improvement of cardiomyocyte contractility and decrease of oxidative stress (Bühler 2009)
  • hypoxia-mediated induction of UCN2 may help to preserve cardiac function and prevent apoptosis in ischaemic condition in the heart (Bühler 2009)
  • suppresses food intake, delays gastric emptying and decreases heat-induced edema
  • activates mitochondrial ATP-sensitive potassium channels and prevents the opening of the mitochondrial permeability transition pore
  • possible involvement of UCN2 and UCN3 in the mechanisms of endometriosis
  • potently suppressed feeding via a CRF-dependent mechanism without eliciting malaise
  • implicated in the regulation of AMPK activation in the heart
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endogenous ligand for CRF type 2 receptors (CRHR2) (induced macrophage apoptosis in a dose- and time-dependent manner via CRHR2)
  • although not amidated, UCN2 prohormone purified from overexpressing lines activated CRF receptor 2
  • binds with high affinity to type 2 CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/reperfusion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in preeclamptic (PE) placentae, the increased expression of UCN2, UCN3 may reflect a response to the oxidative stress
    Susceptibility to abdominal aortic aneurysm (AAA)
    Variant & Polymorphism other is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis
    Candidate gene
    Marker
  • TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively
  • Therapy target
    ANIMAL & CELL MODELS
  • male Ucn2 null mice showed more passive social interactions and reduced aggressiveness in comparison to wild-type animals