protein
| with PSMD8 and TREX2 |
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recruited to proteasomes, through ADRM1 |
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interacts with SMADs and regulates TGF-beta signalling |
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associated in the nucleus with INO80 chromatin-remodeling complex (Yao 2008) |
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binds proteasome through ADRM1, which in turn is bound to the RPN2 subunit of the 19S complex (Yao 2006) |
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only UCH family protease that interacts with the 19S proteasome regulatory complex and disassembles Lys48-linked poly-ubiquitin from the distal end of the chain (Nishio 2009) |
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can interact with larger adducts such as ubiquitin (Nishio 2009) |
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PI3K-dependent UCHL5 is required for high glucose-induced TGFBR1 protein expression in mesangial cells |
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is also required for high glucose-induced TGFBR1 protein deubiquitination, CDKN1A and fibronectin protein expression and cell hypertrophy |
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UCHL5 is a de-ubiquitinating enzyme that is activated by ADRM1 and involved in the proteasomal degradation of proteins |
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ADMR1 can activate UCHL5 by disrupting dimerization, although physiologically relevant activation likely results from stabilization of a surface competent for ubiquitin binding and modulation of the active-site crossover loop |
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UCHL5 expression is induced by E2F1, and its level rises in G1/S transition and S phase, suggesting a positive feedback loop between UCHL5 and E2F1 |
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interacts with TCF7 (formerly named Tcf1) to activate Wnt signalling |
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PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics |
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UCHL5 could inhibit migration and invasion of glioma cells via down regulating expression of SNRPF |
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UCHL5 is required for both the stabilization and the polymerization of AXIN1 proteins |
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UCHL5 controls CTNNB1 destruction complex function through AXIN1 regulation |
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