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FLASH GENE
Symbol UBXN7 contributors: mct/npt - updated : 10-06-2020
HGNC name UBX domain protein 7
HGNC id 29119
Location 3q29      Physical location : 196.080.370 - 196.159.345
Synonym name
  • KIAA0794 protein
  • UBX domain-containing protein 7
    • Synonym symbol(s) KIAA0794, UBXD7
    DNA
    TYPE functioning gene
    STRUCTURE 106.66 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 10521 54 489 - 2012 22537386
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas   moderately
    Reproductivefemale systemovary  predominantly
     male systemtestis  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ubiquitin-associated (UBA) domain at the N terminus
    • HOMOLOGY
    interspecies homolog to yeast Cdc48
    Homologene
    FAMILY
  • UBA-UBX proteins family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • reported to be present both in the cytoplasm as well as the nucleus
    • basic FUNCTION
  • having two-step function in mediating HIF1A degradation via the VCP pathway
  • UBXN7 protein is a ubiquitination substrate of the mitochondrial MUL1 E3 ligase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • links VCP to the ubiquitin ligase CUL2/VHL and its substrate hypoxia-inducible factor 1A (HIF1A)
  • UBXD7, associate only with the active, NEDD8- or Rub1-modified form of cullins
  • UBXN7 directly interacts with neddylated cullins and causes the accumulation of the CUL2 substrate HIF1A
  • UBXN7 interaction with cullins is independent of ubiquitin- and substrate-binding
  • UBXN7 may have a cooperative effect on VCP interaction with UFD1L
  • inactivation of MUL1 ligase leads to accumulation of UBXN7, with concomitant increase in HIF1A protein levels, reduction in oxidative phosphorylation, and increased glycolysis
    • cell & other
    REGULATION
    Other MUL1 ubiquitinates UBXN7 and targets it for degradation by the proteasome
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS