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FLASH GENE
Symbol UBXN2B contributors: mct - updated : 18-05-2011
HGNC name UBX domain protein 2B
HGNC id 27035
Location 8q12.1      Physical location : 59.323.822 - 59.364.059
Synonym name
  • p97 cofactor p37
  • NSFL1 cofactor p37
  • Synonym symbol(s) p37
    DNA
    TYPE functioning gene
    STRUCTURE 40.24 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5088 - 331 - 2010 20875789
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • required for Golgi and ER biogenesis
  • plays an important role in both Golgi and ER maintenance during interphase as well as in their reassembly at the end of mitosis
  • its phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis
  • UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with VCP in the cytosol and localizes to the Golgi and ER
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other mitotically phosphorylated by CDK1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS