| basic FUNCTION
| HECT domain E3 ubiquitin protein-ligase playing a role in regulation of cell proliferation or differentiation |
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playing a role in progesterone receptor signaling but also, in carcinogenesis through DNA damage response pathways |
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regulating transcription independently of its E3 ligase activity |
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necessary role for G(1)/S and intra S phase DNA damage checkpoint activation and for the maintenance of G(2)/M arrest after double strand DNA breaks (Munoz 2007) |
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playing a role in the maintenance of genomic stability, emphasising the potential importance of dysregulated UBR5 expression and/or function in the evolution of cancer (Munoz 2007) |
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specifically enhancing trans-activation of smooth muscle-specific promoters by the myocardin family of proteins |
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can attenuate MYOCD protein degradation (Hu 2010) |
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activator os smooth muscle differentiation (Hu 2010) |
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progestin-regulated gene in breast cancer cells |
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UBR5, as well as UBR1 and UBR2, is associated with the ubiquitination of histone proteins |
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TRIP12 and UBR5, two HECT domain ubiquitin E3 ligases, control accumulation of RNF168, a rate-limiting component of a pathway that ubiquitylates histones after DNA breakage  |
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HECT-domain containing ubiquitin ligase that plays a role in cell proliferation, differentiation and DNA damage response |
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multiple functions, including E3 ligase activity based on a conserved cysteine residue at the C-terminus |
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UBR5, a protein commonly amplified in breast cancer, is a novel regulator of ESR1 protein levels and transcriptional activity |
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UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage |
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UBR5 plays an essential role in gastric cancer |
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UBR7 is a nuclear protein that influences the degradation of an N-end rule substrate and functions together with UBR5 to regulate a NOTCH1 signaling-dependent developmental pathway |
