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FLASH GENE
Symbol UBQLN4 contributors: mct - updated : 04-05-2009
HGNC name ubiquilin 4
HGNC id 1237
Location 1q22      Physical location : 156.005.092 - 156.023.516
Synonym name
  • ataxin 1 ubiquitin-like interacting protein A1U
  • chromosome 1 open reading Frame 6
  • Synonym symbol(s) A1U, UBIN, C1orf6, CIP75
    DNA
    TYPE functioning gene
    STRUCTURE 18.43 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3545 63.7 601 - 2000 11001934
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Reproductivefemale systemuteruscervix  
    cell lineage
    cell lines Purkinge cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal sequence that is very similar to ubiquitin, called the ubiquitin-like domain (UBL)
  • a more variable central domain containing several heat shock chaperonin-binding motifs (STI1 repeats)
  • a conserved 50 AAs sequence called a ubiquitin-associated domain (UBA)
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Ubqln4
    intraspecies homolog to UBQLN2
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of cell survival during starvation
  • protects cells against starvation-induced cell death propagated by overexpression of mutant Alzheimer disease PS2N141I protein
  • a possible function of ubiquilin might be to bind and transport ubiquitinated proteins to autophagosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    binded to endoplasmic reticulum, targeting signal sequence
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ataxin 1, HSP47
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS