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FLASH GENE
Symbol UBN1 contributors: shn - updated : 02-02-2013
HGNC name ubinuclein 1
HGNC id 12506
Location 16p13.3      Physical location : 4.897.911 - 4.932.357
Synonym symbol(s) VT, VT4
DNA
TYPE functioning gene
STRUCTURE 34.45 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map UBN1 was mapped to 16p13.3 by sequencing analysis
Authors Aho et al, 2000
regionally located pter - D16S3084 - D16S3072 - UBN1 - D16S3134 - D16S510 - cent
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 6485 121 1134 - 2000 10725330
18 - 5982 - 1134 - 2000 10725330
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon lowly
 intestinesmall intestine  lowly
 liver   moderately
Endocrinepancreas   highly
Lymphoid/Immunespleen   lowly
 thymus   highly
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
 female systemovary  lowly
 male systemprostate  moderately
 male systemtestis  highly
Respiratorylung   moderately
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines cancer cell lines: Promyelocytic leukemia HL-60, HeLa cells S3, chronic myelogenous leukemia k-562,lymphoblastic leukemia MOLT-4, colorectal adenocarcinoma SW40, lung carcinoma A549 and melanoma G361
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domains of the UBN1 and TJP1 proteins triggered a functional interaction inside the cell
  • five acidic regions
  • a serine-rich domain
  • three main basic nuclear localization signal-like regions
  • a HRD domain (Hpc2p-related domain)
  • a NHRD domain being an essential region for HIRA interaction and chromatin organization by the HUCA complex
  • HOMOLOGY
    interspecies ortholog to Hpc2p, yeast
    ortholog to Ubn1, Mus musculus
    ortholog to zgc:171747, Danio rerio
    ortholog to Ubn1, Rattus norvegicus
    Homologene
    FAMILY member of the bZIP family
    CATEGORY storage , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,nucleolus
    text
  • punctate nuclear staining in cultured keratinocytes
  • UBN1 is localized throughout the nucleoplasm in proliferating primary human fibroblasts
  • basic FUNCTION
  • may be playing a role in maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus
  • UBN1 is indispensable for formation of senescence-associated heterochromatin foci (SAHF)
  • UBN1 is an indispensable component of the HIRA/ASF1a SAHF assembly pathway
  • UBN1 is a regulator of senescence
  • scaffold protein influencing protein subcellular localization and is involved in several processes such as cell-cell contact signalling or modulation of gene activity
  • CELLULAR PROCESS cell life, senescence
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cellular and viral epstein-Barr BLZ1 early gene EB1 transcription factors
  • DKC1, FBL
  • UBN1 binds to the Epstein-Barr virus EB1 protein
  • UBN1 binds to the WD repeats of chromatin regulator HIRA
  • interaction between N-terminal domains of UBN1 and TJP1 proteins inside the cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS