Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBLCP1 contributors: mct - updated : 23-03-2013
HGNC name ubiquitin-like domain containing CTD phosphatase 1
HGNC id 28110
Location 5q33.3      Physical location : 158.690.088 - 158.713.048
Synonym name CTD phosphatase-like with ubiquitin domain 1
Synonym symbol(s) CPUB1, FLJ25267, MGC10067
EC.number 3.1.3.16
DNA
TYPE anonymous DNA segment
STRUCTURE 22.96 kb     11 Exon(s)
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2410 37 318 - 2005 15883030
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative N-terminal ubiquitin-like domain (UBL domain), necessary and sufficient for nuclear localization
  • a FCP1 homology domain
  • a CTD phosphatase domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • nuclear protein that colocalizes with nuclear proteasomes
  • basic FUNCTION
  • may specifically dephosphorylate Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest
  • RNA polymerase II subunit
  • may play a role in the regulation of phosphorylation state of RNA polymerase II C-terminal domain
  • 26S proteasome phosphatase that regulates nuclear proteasome activity
  • selectively represses nuclear proteasome activity in a phosphatase-dependent manner, suggesting a unique mechanism for nuclear proteasome regulation
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    magnesium
    protein
  • directly interacts with the proteasome via its UBL domain and is exclusively localized in the nucleus
  • recruited to the proteasome through direct interaction between its UBL domain and RPN1
  • cell & other
  • proteasome could be a direct substrate of UBLCP1, that is a negative regulator of the proteasome
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    pharmacological inhibition of UBLCP1 will lead to an activation of nuclear proteasomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS