Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBE4B contributors: mct - updated : 23-04-2012
HGNC name ubiquitination factor E4B (UFD2 homolog, yeast)
HGNC id 12500
Location 1p36.22      Physical location : 10.093.015 - 10.241.294
Synonym name
  • ubiquitin degradation protein 2
  • clone 686 protein
  • homozygously deleted in neuroblastoma-1
  • ubiquitin-fusion degradation protein 2
  • Synonym symbol(s) KIAA0684, UFD2, E4, HDNB1, 686, UBOX3
    DNA
    TYPE functioning gene
    STRUCTURE 148.28 kb     28 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390994 1 similar to 60S ribosomal protein L23a ENO1 1p36.2 enolase 1, (alpha) LOC148915 1p36.22 hypothetical LOC148915 CA6 1p36.2 carbonic anhydrase VI LOC390995 1 similar to Solute carrier family 2, facilitated glucose transporter, member 5 (Glucose transporter type 5, small intestine) (Fructose transporter) SLC2A5 1p36.2 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 GPR157 1p36.22 G protein-coupled receptor 157 H6PD 1p36.3 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) SSB1 1p36.22 SPRY domain-containing SOCS box protein SSB-1 MGC4399 1p36.22 mitochondrial carrier protein LOC199953 1p36.22 similar to expressed sequence AV028368 PIK3CD 1p36.2 phosphoinositide-3-kinase, catalytic, delta polypeptide CLSTN1 1p36.22 calsyntenin 1 CTNNBIP1 1pter-p36.31 catenin, beta interacting protein 1 LZIC 1p36.22 leucine zipper and CTNNBIP1 domain containing NMNAT1 1p36.2 nicotinamide nucleotide adenylyltransferase 1 CRBPIV 1p36.22 retinoid binding protein 7 UBE4B 1p36.3- ubiquitination factor E4B (UFD2 homolog, yeast) KIF1B 1p36.2 kinesin family member 1B LOC388593 1 LOC388593 PGD 1p36.31 phosphogluconate dehydrogenase CORT 1p36.3-p36.2 cortistatin DFFA 1p36.3-p36.2 DNA fragmentation factor, 45kDa, alpha polypeptide PEX14 1p36.3-p36.2 peroxisomal biogenesis factor 14 LOC163301 1p36.22 similar to BC035954 protein FLJ20321 1p36.22 hypothetical protein FLJ20321 FLJ37118 1p36.22 hypothetical protein FLJ37118 LOC390996 1 similar to Cofilin, non-muscle isoform TARDBP 1p36.22 TAR DNA binding protein AF311304 1p36.22 hypothetical protein AF311304 MASP2 1p36.3-p36.2 mannan-binding lectin serine protease 2 SRM 1p36-p22 spermidine synthase PMSCL2 1p36.22 polymyositis/scleroderma autoantigen 2, 100kDa FRAP1 1p36.3-p36.2 FK506 binding protein 12-rapamycin associated protein 1 CDT6 1p36.3-p36.2 angiopoietin-like factor TERE1 1p36 angiopoietin-like factor KIAA1337 1p36.21 KIAA1337 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 5503 133 1173 - 2006 16870146
  • N-terminal MPAC domain, which is regulated both by cleavage during cell death, and by phosphorylation during mitosis
  • at the C-terminus polyA polymerase (PAP) domain, which is similarly regulated by phosphorylation during mitosis and is delineated by an apoptotic protease cleavage site
  • 28 - 5890 146 1302 - 2006 16870146
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon lowly
    Lymphoid/Immunethymus   lowly
    Nervousbrainmidbrainsubstantia nigra  
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an U-box domain
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast Ufd2
    homolog to Drosophila Nosa
    homolog to murine Ube4b
    Homologene
    FAMILY
  • ubiquitin conjugation factor E4 family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in multi-ubiquitination chain assembly with E1, E2, E3
  • might play an important role in the regulation of cisplatin mediated cell death mediated by TP63
  • U box-containing protein that functions as an E3 ubiquitin ligase and an E4 polyubiquitin chain elongation factor
  • promotes TP53 polyubiquitination and degradation and inhibits TP53-dependent transactivation and apoptosis
  • negatively regulates the level of TP53 and inhibits TP53-dependent transactivation and apoptosis
  • U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates
  • CELLULAR PROCESS cell cycle
    protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with, and thereby mediated poly-ubiquitylation of ATXN3
  • E3 and E4 ubiquitin ligase, that physically interacts with TP53 and MDM2
  • E3 and E4 ubiquitin ligase with a U-box domain, interacting physically with both TP53 and MDM2
  • TTK is a target of the UBE4B enzyme (UBE4B-mediated TTK degradation is conserved in humans and is important for mitotic progression)
  • cell & other
    REGULATION
    Other proteolytically cleaved by caspases during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of TP53 in brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene targeted expression of UBE4Bis a potential gene therapy for MJD
    Marker
    Therapy target
    ANIMAL & CELL MODELS