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Symbol UBE4A contributors: - updated : 09-11-2005
HGNC name ubiquitination factor E4A (UFD2 homolog, yeast)
HGNC id 12499
Location 11q23.3      Physical location : 118.230.301 - 118.269.924
Synonym name
  • homologous to yeast UFD2
  • Synonym symbol(s) KIAA0126, UFD2, E4, UBOX2
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D11S939 - UBE4A - IL10RA - D11S1341 - D11S1356 - FXYD2 - D11S4104 - RPS25 - CBL - D11S924 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     mouthtongue  highly
    Nervousbrainforebraincerebral cortex  
    Urinarykidneytubule   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    Urinarytubular cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a U-box domain
  • HOMOLOGY
    interspecies homolog to yeast UFD2
    homolog to Drosophila NOSA
    Homologene
    FAMILY ubiquitin conjugation factor E4 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text predominantly expressed in the nucleus and the cytoplasm of cortical neurons and liver and in the nucleus of tubular kidney cells
    basic FUNCTION
  • ubiquitination factor, required for multiubiquitin chain assembly
  • U-box-type ubiquitin ligase, having a specific role in different biochemical processes other than ubiquitination, including growth or differentiation
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component association with E1,E2,E3
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS