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FLASH GENE
Symbol UBE2V1 contributors: mct/npt - updated : 03-07-2013
HGNC name ubiquitin-conjugating enzyme E2 variant 1
HGNC id 12494
Location 20q13.13      Physical location : 48.697.662 - 48.732.494
Synonym name
  • DNA binding protein
  • TRAF6-regulated IKK activator 1 beta Uev1A
  • ubiquitin- conjugating enzyme variant Kua
  • Synonym symbol(s) CROC1, CROC1B, UEV1, CIR1, UEV1A, UBE2V
    DNA
    TYPE functioning gene
    STRUCTURE 34.84 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ARFGEF2 20q13.13 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) SNAP23P 20 synaptosomal-associated protein, 23kDa pseudogene CSE1L 20q13 CSE1 chromosome segregation 1-like (yeast) STAU 20q13.1 staufen, RNA binding protein (Drosophila) ARPC3B 20q13.13 actin related protein 2/3 complex, subunit 3B, 21kDa DDX27 20q13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 KIAA1404 20q13.13 KIAA1404 protein KCNB1 20q13.1 potassium voltage-gated channel, Shab-related subfamily, member 1 PTGIS 20q13.1-q13.3 prostaglandin I2 (prostacyclin) synthase B4GALT5 20q13.1-q13.2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 SNRPFP1 20 small nuclear ribonucleoprotein polypeptide F pseudogene 1 SLC9A8 20q13.13 solute carrier family 9 (sodium/hydrogen exchanger), isoform 8 SPATA2 20q13.1-q13.2 spermatogenesis associated 2 ZNF313 20q13.13 zinc finger protein 313 LOC391256 20 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SNAI1 20q13.2 snail homolog 1 (Drosophila) LOC149738 20q13.13 hypothetical LOC149738 UBE2V1 20q13.2 ubiquitin-conjugating enzyme E2 variant 1 CEBPB 20q13.1 CCAAT/enhancer binding protein (C/EBP), beta COX6CP2 20 cytochrome c oxidase subunit VIc pseudogene 2 PTPN1 20q13.1-q13.2 protein tyrosine phosphatase, non-receptor type 1 LOC200230 20q13.13 similar to KIAA0386 C20orf175 20 chromosome 20 open reading frame 175 RPL36P2 20q13.1 ribosomal protein L36 pseudogene 2 PARD6B 20q13.13 par-6 partitioning defective 6 homolog beta (C. elegans) BCAS4 20q13.13-q13.2 breast carcinoma amplified sequence 4 TMSL6 20 thymosin-like 6 ADNP 20q13.3-q13.2 activity-dependent neuroprotector PSMD10P 20q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene DPM1 20q13.13 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit MOCS3 20 molybdenum cofactor synthesis 3 KCNG1 20q13 potassium voltage-gated channel, subfamily G, member 1 LAMR1P1 20q13.3 laminin receptor 1 pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2541 19.3 170 - 2007 17709375
  • encoding the same protein than variant 1
  • 5 - 2554 19.3 170 - 2007 17709375
  • encoding the same protein than variant 2
  • 4 - 2179 - 103 - 2007 17709375
  • differring in the 5' UTR and coding region compared to variant 1
  • lacking an alternate in-frame exon compared to variant 1
  • 3 - 2392 - 103 . localized to the cytoplasm 2007 17709375
  • protein of fusion between KUA and UBE2V1
  • UEV1 B domains
  • 5 - 2333 25 221 . localized to the cytoplasm 2007 17709375
  • protein of fusion between KUA and UBE2V1
  • lacking three alternate exons in the 5' UTR and coding region compared to variant 1
  • UEV1 B domains
  • 4 - 2158 - 147 - 2007 17709375
    5 - 2276 - 105 - 2007 17709375
    5 - 2297 - 105 - 2007 17709375
    4 - 2149 - - - 2007 17709375
    3 - 2032 - - - 2007 17709375
    5 - 2241 - 105 - 2007 17709375
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon moderately
     liver   moderately
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland moderately
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid ,basic
    STRUCTURE
    motifs/domains
  • acidic domain
  • a C terminal basic domain, lacking the critical cysteine residue essential for E2 catalytic activity
  • HOMOLOGY
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text TMEM189-UBEV localize to cytoplasmic structures, indicating that the TMEM189 domain determines the cytoplasmic localization of TMEM189-UBEV
    basic FUNCTION
  • transcriptional activator of FOS promoter
  • potentially involved in the control of differentiation
  • ubiquitin dependent proteolytic
  • regulation of DNA repair
  • regulation of progression through cell cycle
  • regulation of transcription, DNA-dependent
  • E2-like protein involved in substrate ubiquitin binding
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription, regulation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component UBE2N heterodimerizes with UBE2V1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • fused with TMEM189 (addition of a TMEM189 domain to UBE2V1 in the fused TMEM189-UBE2V1 protein confers new biological properties to this regulator of variant polyubiquitination)
  • TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBE2N and UBE2V1 to catalyse Lys 63-linked polyubiquitination, which activates the MAP3K7 kinase complex
  • interactions between TRIM32 and UBE2V2, and UBE2V1
  • function of TRIM5 is dependent on its association with the E2 ubiquitin-conjugating enzyme complex UBE2N-UBE2V1 and subsequent activation of the MAP3K7 complex and downstream genes involved in innate immune responses
  • UBE2N is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hormone refractory prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS