basic FUNCTION
| having a ligase activity |
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required for postreplication repair of UV-damaged DNA |
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dispensable in a normal mitosis, but its depletion prolongs drug-induced mitotic arrest and suppresses mitotic slippage (Garnett 2009) |
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elongates ubiquitin chains initiated by the E2 enzymes UBE2C, and UBE2D1 enhancing the degradation of ANAPC substrates by the proteasome (Garnett 2009) |
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functions with the ANAPC in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC activation (Garnett 2009) |
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with UBE2C, likely constitute the physiological E2 module for the ANPC during mitosis, in which UBE2C initiates and UBE2S elongates K11-linked ubiquitin chains (Williuamson 2009) |
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with UBE2C, constitute a physiological E2-module for ANAPC, the activity of which is required for spindle assembly and cell division (Williuamson 2009) |