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FLASH GENE
Symbol UBE2S contributors: mct/npt - updated : 22-01-2010
HGNC name ubiquitin-conjugating enzyme E2S
HGNC id 17895
Location 19q13.42      Physical location : 55.912.649 - 55.919.325
Synonym name
  • ubiquitin-protein ligase
  • ubiquitin carrier protein
  • ubiquitin-conjugating enzyme E2-24 kD
  • Synonym symbol(s) E2-EPF, E2-EPF5, EPF5
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 6.68 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1207 - 222 - Garnett (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland  
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine residue required for ubiquitin-thiolester formation
  • HOMOLOGY
    interspecies homolog to murine Ube2s
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • having a ligase activity
  • required for postreplication repair of UV-damaged DNA
  • dispensable in a normal mitosis, but its depletion prolongs drug-induced mitotic arrest and suppresses mitotic slippage (Garnett 2009)
  • elongates ubiquitin chains initiated by the E2 enzymes UBE2C, and UBE2D1 enhancing the degradation of ANAPC substrates by the proteasome (Garnett 2009)
  • functions with the ANAPC in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC activation (Garnett 2009)
  • with UBE2C, likely constitute the physiological E2 module for the ANPC during mitosis, in which UBE2C initiates and UBE2S elongates K11-linked ubiquitin chains (Williuamson 2009)
  • with UBE2C, constitute a physiological E2-module for ANAPC, the activity of which is required for spindle assembly and cell division (Williuamson 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • critical, unique component of the ANAPC ubiquitination pathway (Wu 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAD18
  • targeting von Hippel-Lindau (VHL) for proteosomal degradation in cells, thereby stabilizing hypoxia-inducible factor (HIF)-1alpha (Lim 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS