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FLASH GENE
Symbol UBE2R2 contributors: - updated : 16-09-2004
HGNC name ubiquitin-conjugating enzyme E2R 2
HGNC id 19907
Location 9p11.2      Physical location : 33.817.181 - 33.920.399
Synonym name ubiquitin-conjugating enzyme UBC3B
Synonym symbol(s) UBC3B, CDC34B, FLJ20419, MGC10481
DNA
TYPE functioning gene
STRUCTURE 100.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
bA255A11.3 9p12 FLJ35740 pseudogene LOC389711 9 similar to hypothetical protein DKFZp434F1719 TRBV20OR9-2 9p21 T cell receptor beta variable 20/OR9-2 ANXA2P2 9p13 annexin A2 pseudogene 2 TRBV21OR9-2 9p21 T cell receptor beta variable 21/OR9-2 TRBV22OR9-2 9p21 T cell receptor beta variable 22/OR9-2 TRBV23OR9-2 9p21 T cell receptor beta variable 23/OR9-2 TRBV24OR9-2 9p21 T cell receptor beta variable 20/OR9-2 TRBV25OR9-2 9p21 T cell receptor beta variable 25/OR9-2 PTENP1 9p21 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1 TRBVAOR9-2 9p21 T cell receptor beta variable A/OR9-2 TRBV26OR9-2 9p21 T cell receptor beta variable 26/OR9-2 TRBV29OR9-2 9p21 T cell receptor beta variable 29/OR9-2 PRSS3 7q35 protease, serine, 3 (mesotrypsin) UBE2R2 9p11.2 ubiquitin-conjugating enzyme E2R 2 UBAP2 9p13.2 ubiquitin associated protein 2 KIAA1892 9p11.2 KIAA1892
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
UBC catalytic domain
HOMOLOGY
interspecies homolog to murine Ube2r2
homolog to rattus LOC299677
Homologene
FAMILY E2 ubiquitin-conjugating enzyme family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzes the attachment of ubiquitin to others proteins for proteolysis
  • enhances beta-catenin degradation as a result of its interaction with beta-TRCp
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with BTRC
    cell & other
    REGULATION
    Other phosphorylated by CK2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS