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FLASH GENE
Symbol UBE2L6 contributors: mct - updated : 20-02-2012
HGNC name ubiquitin-conjugating enzyme E2L 6
HGNC id 12490
Location 11q12      Physical location : 57.319.128 - 57.335.453
Synonym name
  • retinoic acid induced gene B protein
  • Synonym symbol(s) UBCH8, RIGB, RIG-B
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 16.68 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC219522 11q12.1 similar to Olfactory receptor 5AK3 LOC390181 11 similar to Olfactory receptor 5AK2 LOC390182 11 similar to Olfactory receptor 5AK2 LOC219525 11q12.1 olfactory-like receptor (PJCG3) pseudogene LOC219527 11q12.1 similar to expressed sequence AI841794 AGTRL1 11q12 angiotensin II receptor-like 1 TNKS1BP1 11q12.2 tankyrase 1 binding protein 1, 182kDa SSRP1 11q12.1-q12.2 structure specific recognition protein 1 P2RX3 11q12 purinergic receptor P2X, ligand-gated ion channel, 3 PRG3 11q12 proteoglycan 3 PRG2 11q12 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) EEG1 11q11 likely ortholog of mouse embryonic epithelial gene 1 NGRH1 SLC43A1 11p11.2-p11.1 solute carrier family 43, member 1 TIMM10 11q12.1-q12.3 translocase of inner mitochondrial membrane 10 homolog (yeast) LOC219537 11q12.1 similar to RIKEN cDNA 1110030K22 UBE2L6 11q12 ubiquitin-conjugating enzyme E2L 6 LOC390183 11 similar to ribosomal protein S4, X-linked SERPING1 11q12.1 serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) FLJ30213 11q12.1 hypothetical protein FLJ30213 HEAB 11q12 hypothetical protein FLJ30213 ZDHHC5 11q12.2 zinc finger, DHHC domain containing 5 LCMR1 11q12.1 lung cancer metastasis-related protein 1 TMX2 11cen-q22.3 thioredoxin-related transmembrane protein 2 SELH 11q12.1 selenoprotein H CTNND1 11q11 catenin (cadherin-associated protein), delta 1 LOC390184 11 similar to seven transmembrane helix receptor LOC283193 11q12.1 similar to seven transmembrane helix receptor HCP26 11q12.1 cytochrome c, somatic pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 1283 17 153 - 2000 10894956
    4 splicing 1269 10 87 - 2000 10894956
  • containing an alternate 5' exon
  • using a downstream start codon compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   moderately
    Hearing/Equilibriumear   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  moderately
     female systemuterus  moderately
    Respiratorylung   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion blood, lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved UBC domain of 150 aa harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • HOMOLOGY
    interspecies homolog to rattus Ube2l6 (73.9pc)
    homolog to murine Ube2l6 (75.7pc)
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • UBE2E family of UBCs
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • functioning in the E6/E6-AP-induced ubiquitination of p53/TP53
  • implicated primarily in processes in the nucleus, is a previously unrecognized important modulator of leukemic cell survival
  • ubiquitylates and promotes the degradation of CDKN1A, both during the normal cell cycle and in UV-irradiated cells
  • CELLULAR PROCESS cell cycle
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • second step of ubiquitin conjugation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin protein ligase in the E6-dependent ubiquination of TP53
  • both UBE2L3 and UBE2L6 bind to RNF19B
  • targets active FMS-like tyrosine kinase 3 (FLT3) for proteasomal degradation
  • RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS