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FLASH GENE

Symbol

UBE2L6

contributors: mct - updated : 20-02-2012

HGNC name	ubiquitin-conjugating enzyme E2L 6
HGNC id	12490

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12      Physical location : 57.319.128 - 57.335.453
Synonym name	retinoic acid induced gene B protein
Synonym symbol(s)	UBCH8, RIGB, RIG-B
EC.number	6.3.2.19

DNA

TYPE	functioning gene
STRUCTURE	16.68 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004223 4 splicing 1283 NP_004214 17 153 - 2000 10894956 NM_198183 4 splicing 1269 NP_937826 10 87 - 2000 10894956 containing an alternate 5' exon using a downstream start codon compared to variant 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       moderately Hearing/Equilibrium ear       highly Lymphoid/Immune tonsils       highly Reproductive female system ovary     moderately   female system uterus     moderately Respiratory lung       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately

cell lineage
cell lines
fluid/secretion	blood, lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved UBC domain of 150 aa harboring the cysteine residue required for enzyme-ubiquitin thioester formation

HOMOLOGY

interspecies	homolog to rattus Ube2l6 (73.9pc)
	homolog to murine Ube2l6 (75.7pc)

Homologene

FAMILY	ubiquitin-conjugating enzyme family
	UBE2E family of UBCs

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the covalent attachment of ubiquitin to other proteins
	functioning in the E6/E6-AP-induced ubiquitination of p53/TP53
	implicated primarily in processes in the nucleus, is a previously unrecognized important modulator of leukemic cell survival
	ubiquitylates and promotes the degradation of CDKN1A, both during the normal cell cycle and in UV-irradiated cells

CELLULAR PROCESS	cell cycle
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

second step of ubiquitin conjugation

a component

INTERACTION

DNA

RNA

small molecule

protein	identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin protein ligase in the E6-dependent ubiquination of TP53
	both UBE2L3 and UBE2L6 bind to RNF19B
	targets active FMS-like tyrosine kinase 3 (FLT3) for proteasomal degradation
	RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS