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FLASH GENE
Symbol UBE2L3 contributors: mct - updated : 02-10-2018
HGNC name ubiquitin-conjugating enzyme E2L 3
HGNC id 12488
Location 22q11.21      Physical location : 21.921.956 - 21.978.323
Synonym name
  • ubiquitin carrier protein
  • ubiquitin-protein ligase
  • Synonym symbol(s) UBCH7, E2-F1, L-UBC, UbcM4
    EC.number 6.3.2.19/2.3.2.23
    DNA
    TYPE functioning gene
    STRUCTURE 74.59 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure no TATA or CAAT,binding sites for AP2, Sp1
    MAPPING cloned Y linked N status confirmed
    Map cen - UBE2L3 - D22S446 - D22S1014E - D22S1003E - qter
    Authors Moynihan (98)
    Physical map
    SLC7A4 22q11.21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 LOC391301 22 similar to Tubulin alpha-3/alpha-7 chain (Alpha-tubulin 3/7) LOC388858 22 similar to Bcr protein LOC391302 22 hypothetical gene supported by AY358961; NM_014549 LOC376818 22q11.22 E2F transcription factor 6 pseudogene LOC388859 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC388860 22 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC388861 22 similar to E2F transcription factor 6 isoform a LOC388862 22 LOC388862 LOC388863 22 similar to dJ831C21.3 (novel protein similar to DKFZP434P211 protein) LOC388864 22 similar to breakpoint cluster region isoform 1 LOC391303 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC391304 22 similar to KIAA0649 gene product LOC391305 22 similar to Sushi domain (SCR repeat) containing KIAA1666  KIAA1666 protein HIC2 22q11.21 hypermethylated in cancer 2 LOC220686 22q11.22 hypothetical protein LOC220686 LOC150221 22q11.22 similar to hypothetical protein UBE2L3 22q11.22 ubiquitin-conjugating enzyme E2L 3 LOC150223 22q11.22 hypothetical protein LOC150223 FLJ36046 22q11.22 hypothetical protein FLJ36046 SDF2L1 22q11.22 stromal cell-derived factor 2-like 1 LOC388865 22 similar to RIKEN cDNA 2610318N02 PPIL2 22q11.22 peptidylprolyl isomerase (cyclophilin)-like 2 YPEL1 22q11.2 yippee-like 1 (Drosophila) MAPK1 22q11.2 mitogen-activated protein kinase 1 PPM1F 22q11.22 protein phosphatase 1F (PP2C domain containing) FLJ23185 22q11.22 hypothetical protein FLJ23185 TOP3B 22q11 topoisomerase (DNA) III beta LOC391306 22 similar to Hypothetical protein DJ1198H6.2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2907 - 154 - 1998 9693040
    3 - 2932 - 122 - 1998 9693040
    4 - 3007 - 212 - 1998 9693040
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • HOMOLOGY
    intraspecies homolog to L-UBC (UBE2L1)
    Homologene
    FAMILY ubiquitin-conjugating enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ubiquitin dependent proteolytic, mediating the selective degradation of short-lived and abnormal proteins
  • ubiquitin conjugating enzyme mediating c-fos degradation NFKB maturation, human papilloma virus TP53 and MYC degradation in vitro
  • dynamic cell cycle-dependent changes in levels of UBE2L3 regulate entrance into and progression through S phase
  • potential role for its targets in the completion of S phase and entry into G2
  • promotes S phase progression to G2 by modulating the intra-S phase checkpoint mediated by CHEK1
  • reported to function with members of the RING E3 family known as RBRs, which includes parkin and ARIH1
  • exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes PARK2 and ARIH1
  • regulates both the steady-state and replicative stress-induced ubiquitination and proteasome-dependent degradation of the tumor suppressor TP53-binding protein 1 (TP53BP1)
  • important role for UBE2L3 in plasmablast and plasma cell development
  • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBOX5
  • ARIH1 interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
  • both UBE2L3 and UBE2L6 bind to RNF19B
  • interaction between the E3 ubiquitin ligase ITCH and the E2 UBE2L3
  • binding UBE3A
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
  • MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway
  • NDFIP1 acts as an adaptor for UBE2L3 and ITCH
  • controls IL1B secretion by inflammasomes
  • CASP1, controls pyroptosis- and ubiquitin-independent proteasomal degradation of UBE2L3 upon canonical and non-canonical inflammasome activation by sterile danger signals and bacterial infection
  • specifically protects CDKN1B from degradation
  • UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on CDKN1B that are proteolytically incompetent
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Crohn disease
  • to Hashimoto thyroiditis (HT)
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • rs2298428 in UBE2L3 significantly associated with Crohn disease
  • TCGGC haplotype is associated with an increased risk of HT in a Chinese Han population
  • variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBE2L3 expression
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS