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FLASH GENE
Symbol UBE2J2 contributors: - updated : 09-02-2006
HGNC name ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
HGNC id 19268
Location 1p36.33      Physical location : 1.189.293 - 1.209.234
Synonym name
  • yeast UBC6 homolog
  • ubiquitin conjugating enzyme 6
  • non-canonical ubiquitin-conjugating enzyme 2
  • Synonym symbol(s) Ubc6p, NCUBE2, PRO2121
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 19.00 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC338718 1p36.33 similar to Olfactory receptor 4F3 LOC388578 1 similar to F-box only protein 25 FLJ39207 1q42.12 C219-reactive peptide FLJ22639 1p36.33 hypothetical protein FLJ22639 LOC284591 1p36.33 hypothetical protein LOC284591 LOC388773 1 similar to chromosome 14 open reading frame 24 LOC388579 1 similar to beta-tubulin 4Q LOC388580 1 hypothetical gene supported by AF148950 FLJ20584 1p36.33 hypothetical protein FLJ20584 LOC390987 1 similar to F12M16.16 FLJ36119 1p36.33 hypothetical protein FLJ36119 TNFRSF18 1p36.3 tumor necrosis factor receptor superfamily, member 18 TNFRSF4 1p36 tumor necrosis factor receptor superfamily, member 4 Cab45 1p36.33 calcium binding protein Cab45 precursor B3GALT6 1p36.33 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 LOC388581 1 similar to RIKEN cDNA 1110035L05 UBE2J2 1p36.33 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) SCNN1D 1p36.33 sodium channel, nonvoltage-gated 1, delta CENTB5 1p36 centaurin, beta 5 FLJ90811 1p36.33 hypothetical protein FLJ90811 LOC388774 1 similar to hypothetical protein FLJ20542 1p36.33 hypothetical protein FLJ20542 TAS1R3 1p36.33 taste receptor, type 1, member 3 DVL1 1p36.33 dishevelled, dsh homolog 1 (Drosophila) MGC3047 1p36.33 hypothetical protein MGC3047 AKIP 1p36.33 aurora-A kinase interacting protein LOC388775 1 similar to testis-specific protein NYD-TSP1 MRPL20 1p36.3-36.2 mitochondrial ribosomal protein L20 LOC391207 1 LOC391207 LOC388582 1 LOC388582 WARP 1p36.33 von Willebrand factor A domain-related protein FLJ37183 1p36.33 FLJ37183 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2315 - 275 - Tiwari
    eight exons
    - - 2267 28.9 259 ovary Tiwari
    seven exons (lacking an in-frame internal exon)
    - splicing 2396 - 207 - Tiwari
    seven exons, two alternate splice sites in the 5' region, using a downstream start codon
    - - 2389 - 105 - Tiwari
    eight exons (lacks an in-frame internal exon but has a downstream additional exon). Isoform 4 miss an internal segment and has a much shorter and distinct C-terminus, as compared to isoform 1
    - - 2136 - 207 - Tiwari
    six exons (lacks two consecutive exons and uses a downstream start codon)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Lymphoid/Immunelymph node    
    Nervousbrain    
    Reproductivefemale systemuteruscervix  
     female systemplacenta   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    UBC catalytic domain
    HOMOLOGY
    interspecies homolog to rattus LOC298689
    ortholog to murine Ube2j2
    Homologene
    FAMILY ubiquitin-conjugating enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • catalyzes the attachment of ubiquitin to proteins (may function selectively on misfolded membran proteins from the endoplasmic reticulum)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus LOC298689
    ortholog to murine Ube2j2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION involved in protein modification, ubiquitin cycle.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Parkinson's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS