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FLASH GENE
Symbol UBE2J1 contributors: mct/shn - updated : 31/01/2011
HGNC name ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
HGNC id 17598
Location 6q15      Physical location : 90.036.344 - 90.062.619
Synonym name
  • HSUBC6e
  • non-canonical ubiquitin-conjugating enzyme 1
  • non-canonical ubquitin conjugating enzyme 1
  • ubiquitin-conjugating enzyme E2 J1
  • yeast ubiquitin-conjugating enzyme UBC6 homolog E
  • Synonym symbol(s) CGI-76, HSPC153, HSPC205, HSU93243, MGC12555, NCUBE-1, NCUBE1, Ubc6p, UBC6e
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 26.28 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S1595 - D6S1644 - UBE2J1 - D6S1613 - D6S462 - qter
    Physical map
    C6orf163 6q15 chromosome 6 open reading frame 163 C6orf165 6q15 chromosome 6 open reading frame 165 TAF13P 6q14.3-15 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene SLC35A1 6q16.1 solute carrier family 35 (CMP-sialic acid transporter), member A1 RARSL 6q16.1 arginyl-tRNA synthetase-like ORC3L 6q14.3-16.3 origin recognition complex, subunit 3-like (yeast) C6orf166 6q15 chromosome 6 open reading frame 166 SPACA1 6q16.1 sperm acrosome associated 1 CNR1 6q14-q15 cannabinoid receptor 1 (brain) LOC391951 6 similar to ribosomal protein S14 ACTBP8 6q13 actin, beta pseudogene 8 RNGTT 6q16 RNA guanylyltransferase and 5'-phosphatase HCP16 6q15 cytochrome c, somatic pseudogene PNRC1 6q16.1 proline-rich nuclear receptor coactivator 1 SRrp35 6q16.1 serine-arginine repressor protein (35 kDa) ACY1L2 6q16.1 aminoacylase 1-like 2 GABRR1 6q13-q15.3 gamma-aminobutyric acid (GABA) receptor, rho 1 GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2 UBE2J1 6q16.1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) RRAGD 6q15-q16 Ras-related GTP binding D ANKRD6 6q14.2-q16.1 ankyrin repeat domain 6 DJ122O8.2 6q14.2-q16.1 hypothetical protein dJ122O8.2 MDN1 6q15 MDN1, midasin homolog (yeast) CASP8AP2 6q16.1 CASP8 associated protein 2 CX62 6q15-q16 connexin 62 LOC285793 6q16.1 hypothetical LOC285793 BACH2 6q15 BTB and CNC homology 1, basic leucine zipper transcription factor 2 MAP3K7 6q16.1-q16.3 mitogen-activated protein kinase kinase kinase 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4360 - 318 - 2006 16720581
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text umbilical cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Ube2j1, Mus musculus
    ortholog to Ube2j1, Rattus norvegicus
    ortholog to UBE2J1, Pan troglodytes
    Homologene
    FAMILY tail-anchored (TA) membrane proteins
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • catalyzes the attachment of ubiquitin to other proteins to allow their degradation
  • acting as an E2 ubiquitin ligase
  • essential role for SYVN1 together with the E2 ubiquitin-conjugating enzyme UBE2J1 in the ubiquitination and dislocation of misfolded MHC class I heavy chains
  • physiological role for SYVN1 and UBE2J1 in the homeostatic regulation of MHC class I assembly and expression
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SYVN1 and UBE2J1 form a functional E3E2 pair for the turnover of other ERAD cellular substrates
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding misfolded membrane protein
  • intearacting with AUP1, and FAF2 (are required for the exit of a type I ER membrane protein from the ER)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS