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FLASH GENE
Symbol UBE2G2 contributors: mct/pgu - updated : 21-10-2011
HGNC name ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
HGNC id 12483
Location 21q22.3      Physical location : 46.188.955 - 46.221.738
Synonym name ubiquitin conjugating enzyme G2
Synonym symbol(s) UBC7
EC.number 6.3.2.19
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 32.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ICOSL 21q22.3 inducible T-cell co-stimulator ligand DNMT3L 21q22.3 DNA (cytosine-5-)-methyltransferase 3-like AIRE 21q22.3 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) PFKL 21q22.3 phosphofructokinase, liver C21orf2 21q22.3 chromosome 21 open reading frame 2 TRPM2 21q22.3 transient receptor potential cation channel, subfamily M, member 2 LRRC3 21q22.3 leucine-rich repeat-containing 3 C21orf29 21q22.3 chromosome 21 open reading frame 29 C21orf90 21q22.1 chromosome 21 open reading frame 90 KRTAP10-10 21q22.3 keratin associated protein 10-10 KRTAP12-2 21q22.3 keratin associated protein 12-2 IMMTP 21q22.3 inner membrane protein, mitochondrial (mitofilin) pseudogene KRTAP12-1 21q22.3 keratin associated protein 12-1 UBE2G2 21q22.3 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) SMT3H1 21q22.3 SMT3 suppressor of mif two 3 homolog 1 (yeast) PTTG1IP 21q22.3 pituitary tumor-transforming 1 interacting protein ITGB2 21q22.3 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) C21orf69 21q22.3 chromosome 21 open reading frame 69 C21orf67 21q22.3 chromosome 21 open reading frame 67 C21orf70 21q22.3 chromosome 21 open reading frame 70 LOC391283 21 similar to interspersed repeat antigen, putative C21orf122 21q22.3 chromosome 21 open reading frame 122 ADARB1 21q22.3 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) C21orf89 21q22.1 chromosome 21 open reading frame 89 C21orf80 21q22.3 chromosome 21 open reading frame 80
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2919 2.9 165 - 2006 16582478
- - 3034 - 137 ubiquitous 2006 16582478
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150 AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • extra loop region interacting with the RING domain or its neighbouring region and may be involved in the binding specificity and stability
  • secondary structure alpha/beta protein with four alpha-helices and a four-stranded antiparallel beta-sheet
    HOMOLOGY
    interspecies homolog to yeast UBC7
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic E2 ubiquitin ligase
    basic FUNCTION
  • involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation
  • UBE2G1 and UBE2G2 cooperate with IL17RB to polyubiquitylate and degrade CDT1 postradiation, an activity that is critical for preventing origin licensing in DNA-damaged cells
  • acts as the E2-conjugating enzyme for AMFR, another E3 ubiquitin ligase that specializes in the ubiquitylation of dislocated ER proteins
  • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between TRIM9 and UBE2G2
  • AUP1 binds UBE2G2 and this interaction is dependent on the C terminus of AUP1 that constitutes a G2BR domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS