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FLASH GENE
Symbol UBE2E1 contributors: mct - updated : 26-10-2011
HGNC name ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
HGNC id 12477
Location 3p24.2      Physical location : 23.847.438 - 23.932.802
Synonym name
  • ubiquitin carrier protein E1
  • ubiquitin-protein ligase E1
  • Synonym symbol(s) UBCH6
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 85.75 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    Physical map
    RAB5A 3p24-p22 RAB5A, member RAS oncogene family LOC391517 3 similar to Heat shock cognate 71 kDa protein FLJ25449 3p24.3 hypothetical protein MGC27069 PCAF 3p24 p300/CBP-associated factor LOC151648 3p24.3 hypothetical protein BC001339 LOC391518 3 hypothetical gene supported by X74864 FLJ22419 3p24.3 hypothetical protein FLJ22419 LOC389099 3 similar to RIKEN cDNA B830010L13 gene HMG1L5 3p24 high-mobility group (nonhistone chromosomal) protein 1-like 5 LOC391519 3 similar to SALL4B FLJ25157 3p24.2 hypothetical protein FLJ25157 UBE2E1 3p24.1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) KBRAS1 3p24.1 I-kappa-B-interacting Ras-like protein 1 RPL15 3p12-p11.2 ribosomal protein L15 NR1D2 3p24.3-p24.2 nuclear receptor subfamily 1, group D, member 2 LOC391520 3 similar to nucleolar phosphoprotein B23.2 - rat THRB 3p24 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) LOC285324 3p24.1 similar to Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein) LOC391521 3 similar to Cofilin, non-muscle isoform LOC51036 3p24 retinoic acid receptor-beta associated open reading frame RARB 3p24.3 retinoic acid receptor, beta TOP2B 3p24 topoisomerase (DNA) II beta 180kDa LOC391522 3 similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) NGLY1 3p24.1 N-glycanase 1 LOC246135 3p24.1 TBP-associated factor 9-like pseudogene FLJ12409 3p24.1 hypothetical protein FLJ12409 FLJ20604 3p24.1 hypothetical protein FLJ20604 LOC285326 3p24.1 hypothetical protein LOC285326 LOC391523 3 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) VENTX2P4 3p24.1 VENT-like homeobox 2 pseudogene 4 LRP15 3p24 hypothetical protein LRP15 FLJ32685 3p24.1 hypothetical protein FLJ32685 SLC4A7 3p22 solute carrier family 4, sodium bicarbonate cotransporter, member 7 LOC285321 3p23 similar to tropomyosin 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1845 - 193 - 2005 16428300
    5 - 1794 - 176 - 2005 16428300
    - - 1550 - 160 - 2005 16428300
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY E2 ubiquitin-conjugating enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • UBE2E1 is localized to the nucleus
  • basic FUNCTION
  • E2 enzymes for ubiquitin conjugation, that may be involved in the ubiquitination of various proteins
  • modulates the transcriptional repression activity of ATXN1 by modulating the degradation of ATXN1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UBE2E1-RNF167 may define a novel ubiquitin-proteasome pathway that targets SLC22A18 in cells
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UBE3A
  • interacts with and ubiquitinates ATXN1, the spinocerebellar ataxia type 1 gene product (could ubiquitinate ataxin-1 in the absence of an E3 ligase and modulates its stability)
  • UBE2E1, RNF20/40, and the PAF1 complex are recruited to transcriptionally active genes
  • TRIM21 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS