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FLASH GENE
Symbol UBASH3B contributors: mct - updated : 04-07-2018
HGNC name ubiquitin associated and SH3 domain containing, B
HGNC id 29884
Location 11q24.1      Physical location : 122.526.397 - 122.685.186
Synonym name
  • suppressor of T-cell receptor signaling 1
  • SH3 domain-containing 70 kDa protein
  • Cbl-interacting protein Sts-1
  • T-cell ubiquitin ligand protein 2
  • suppressor of T-cell receptor signaling 1
  • nm23-phosphorylated unknown substrate
  • Synonym symbol(s) p70, KIAA1959, MGC15437, STS-1, TULA-2, STS1, TULA2
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 158.79 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6917 72 649 - 2016 26766443
    14 - 6907 - 614 - 2016 26766443
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   predominantly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ubiquitin associated domain at the N-terminus
  • an SH3 domain
  • a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase, and homology to the 2H-phosphatase family of enzymes , C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates
  • HOMOLOGY
    Homologene
    FAMILY
  • phosphoglycerate mutase family
  • TULA family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inhibiting endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor
  • being a critical regulator of the signaling pathways that regulate T-cell activation
  • implicated in the regulation of signaling mediated by protein tyrosine kinases (PTKs)
  • with UBASH3A, may exert opposite effects on PTK-mediated signaling
  • multidomain proteins that negatively regulate the signaling of membrane-bound receptors, including TCR and the epidermal growth factor receptor (EGFR)
  • function as critical negative regulators of TCR signaling
  • instrumental in down-modulating proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination
  • has a key role in platelet glycoprotein VI (GPVI) signaling
  • primary tyrosine phosphatase mediating the dephosphorylation of SYK and thus functions as a negative regulator of GP6 signaling in platelets
  • recognizes two distinct classes of Tyr(P) substrates and is highly active toward peptides corresponding to the Tyr(P)-323 and Tyr(P)-352 sites of SYK
  • UBASH3A, UBASH3B function as critical negative regulators of TCR signaling
  • may likely play a role during early as well late stages of osteoclast differentiation, and negatively regulates osteoclast differentiation and function
  • may function as a crucial node in bridging multiple invasion-promoting pathways
  • suppress T-cell-driven inflammatory responses
  • pivotal role of UBASH3A/UBASH3B in regulating hematopoietic stem and progenitor cell fitness
  • is an important regulator of mitosis
  • protein-tyrosine phosphatase that has been shown to regulate receptor signaling in several cell types, including platelets
  • control Spindle Assembly Checkpoint (SAC) silencing and faithful chromosome segregation by relocalizing Aurora B kinase to the mitotic microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SYK is a UBASH3B substrate in platelets
  • like INPP5D, functions as a negative regulator of FCER1A signaling in mast cells
  • interacts with ubiquitylated AURKB, one of the main kinases regulating chromosome segregation, and controls its subcellular localization but not protein levels
  • targeting AURKB to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
  • UBASH3B suppresses activation of SYK through the GP6 platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of SYK
  • interaction between UBASH3B and SHC1 is regulated in response to EGF receptor activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of UBASH3B may offer an attractive therapeutic perspective for cancers
    cancerreproductivebreast
    potential therapeutic target for TNBC
    ANIMAL & CELL MODELS
  • Ubash3a/Ubash3b-deficient mice show a profound expansion of multipotent progenitor and lymphoid primed multipotent progenitor cells with elevated colony-forming capacity