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FLASH GENE
Symbol UBAP2L contributors: mct - updated : 09-11-2015
HGNC name ubiquitin associated protein 2-like
HGNC id 29877
Location 1q21.3      Physical location : 154.192.654 - 154.243.328
Synonym name
  • KIAA0144 gene product
  • NICE-4 protein
  • Synonym symbol(s) KIAA0144, NICE-4
    DNA
    TYPE functioning gene
    STRUCTURE 51.56 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3418 - 983 - 2014 25185265
    27 - 3999 - 1078 - 2014 25185265
    25 - 3451 - 976 - 2014 25185265
    27 - 4006 - 1087 - 2014 25185265
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an arginine- and glycine-rich motif called the RGG/RG or GAR motif in the N terminus
  • a ubiquitin-associated (UBA) domain near its N-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • essential for the activity of long-term repopulating hematopoietic stem cells (LT-HSCs)
  • has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development
  • is necessary for correct kinetochore-microtubule attachment
  • possible role for arginine methylation in UBAP2L for the progression of mitosis
  • believed to be involved in the ubiquitin-proteasome pathway
  • may play a role in prostate cancer growth and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • UBAP2L is part of a PcG subcomplex comprising BMI1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBAP2L is a novel BMI1-interacting protein, and is a novel BMI1-interacting protein essential for hematopoietic stem cell activity
  • PRMT1 is a direct interaction partner of UBAP2L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    inhibited chromosome alignment in metaphase and delayed progression to anaphase by activating spindle assembly checkpoint signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS