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FLASH GENE
Symbol UBA7 contributors: npt - updated : 25-08-2008
HGNC name ubiquitin-like modifier activating enzyme 7
HGNC id 12471
Location 3p21.2      Physical location : 49.842.638 - 49.851.391
Synonym name
  • ubiquitin-activating enzyme E1-like
  • UBA1, ubiquitin-activating enzyme E1 homolog B (yeast)
  • UBA7, ubiquitin-activating enzyme E1
  • Synonym symbol(s) UBE1L, D8, UBE2, UBA1B, MGC12713
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 3330 - 1012 - Takeuchi (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ubiquitin-activating E1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • function as E1 enzyme for ISG15 conjugation
  • direct pharmacological target that overcomes oncogenic effects of PML/RARalpha by triggering its degradation and signaling apoptosis in acute promyelocytic leukemia cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction with ISG15 (induced ISG15 conjugation during leukemic cell differentiation implicate an important role for these proteins in retinoid response)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS