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FLASH GENE
Symbol TYSND1 contributors: - updated : 28-05-2007
HGNC name trypsin domain containing 1
HGNC id 28531
Location 10q22.1      Physical location : 71.897.734 - 71.906.496
Synonym symbol(s) FLJ40378, MGC131934, MGC34695
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3802 59 566 - Kurochkin
N-terminal segment (AA 1-110) may represent an inhibitory peptide that restrains the activity of Tysnd1 until it reaches the peroxisomes
- - 3485 49 398 - Kurochkin
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,peroxisome
basic FUNCTION
  • responsible both for the removal of the leader peptide from PTS2 proteins and for the specific processing of PTS1 proteins
  • involved in beta-oxidation of fatty acids
  • major enzyme involved in cellular processing of peroxisomal enzymes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by the proliferator-activated receptor alpha agonist bezafibrate, along with the increase in its substrates
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS