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FLASH GENE
Symbol TYRO3 contributors: mct/npt/pgu - updated : 30-01-2010
HGNC name TYRO3 protein tyrosine kinase
HGNC id 12446
Location 15q15.1      Physical location : 41.851.219 - 41.871.534
Synonym name
  • tyrosine-protein kinase receptor TYRO3 precursor
  • tyrosine-protein kinase DTK
  • tyrosine-protein kinase RSE
  • tyrosine-protein kinase SKY
  • tyrosine-protein kinase byk
  • Tyro3 protein tyrosine kinase (sea-related receptor
  • tyrosine kinase)
    Synonym symbol(s) RSE, SKY, BYK, Brt, Dtk, TIF, FLJ16467
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 20.29 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC20481 15q14 hypothetical protein MGC20481 C18B11 15q13.3 C18B11 homolog (44.9kD) AF15Q14 15q14 AF15q14 protein RAD51 15q15.1 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) FLJ10579 15q14 hypothetical protein FLJ10579 GCHFR 15q15 GTP cyclohydrolase I feedback regulatory protein FLJ10634 15q14 hypothetical protein FLJ10634 ZFYVE19 15q14 zinc finger, FYVE domain containing 19 PPP1R14D 15q13.3 protein phosphatase 1, regulatory (inhibitor) subunit 14D SPINT1 15q15 serine protease inhibitor, Kunitz type 1 ARHV 15q13.3 ras homolog gene family, member V VPS18 15q14-q15 vacuolar protein sorting protein 18 DLL4 15q14 delta-like 4 (Drosophila) MGC4504 15q14 hypothetical protein MGC4504 KIAA1259 15q14 hypothetical protein MGC4504 HCP37 15q15.1 cytochrome c, somatic pseudogene LOC388116 15 similar to RIKEN cDNA 6720467C03 MGC33637 15q14 hypothetical protein MGC33637 CHP 15q13.3 hypothetical protein MGC33637 OIP5 15q14 Opa-interacting protein 5 NUSAP1 15q14 nucleolar and spindle associated protein 1 CIA30 KIAA0252 15q14 nucleolar and spindle associated protein 1 ITPKA 15q14-q21 inositol 1,4,5-trisphosphate 3-kinase A LTK 15q15.1-q15.2 leukocyte tyrosine kinase DKFZP727M111 15q14 DKFZP727M111 protein LOC283747 15q14 similar to elongation factor SIII p15 subunit TYRO3 15q15.1-q21.1 TYRO3 protein tyrosine kinase MGA 15q15 MAX gene associated MAPKBP1 15q14 likely ortholog of mouse mitogen activated protein kinase binding proten 1 PLA2G4B 15q11.2-q21.3 phospholipase A2, group IVB (cytosolic) SPTBN5 15q21 spectrin, beta, non-erythrocytic 5 EHD4 15q11.1-q15 EH-domain containing 4 FLJ45651 15q14 FLJ45651 protein LOC388117 15 LOC388117 cPLA2delta LOC255189 15q14 hypothetical protein LOC255189 VPS39 15q14-q15 vacuolar protein sorting 39 (yeast) DKFZP564G2022 15q14 DKFZP564G2022 protein GANC 15q15.1-q15.2 glucosidase, alpha; neutral C CAPN3 15q15.1-q15.3 calpain 3, (p94) ZFP106 15q14 zinc finger protein 106 homolog (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3949 96.8 890 - 2005 15964779
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-like domains linked to two fibronectin, type III repeats
  • cytoplamic region that contains an intrinsic protein tyrosine kinase domain
  • a conserved sequence within the kinase domain and adhesion molecule-like extracellular domains
  • HOMOLOGY
    Homologene
    FAMILY
  • TAM family of receptor tyrosine kinases (RTKs)
  • protein kinase superfamily
  • Tyr protein kinase family
  • AXL/UFO subfamily
  • CATEGORY enzyme , protooncogene , receptor membrane G tyrosine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in the protection of neurons from apoptosis
  • involved in the regulation of spermatogenesis
  • involved in cell adhesion
  • Tyro 3 RTK subfamily plays important roles in regulating hemostasis, megakaryocytopoiesis and platelet function
  • Tyro 3 RTK subfamily plays important roles in regulating hemostasis, megakaryocytopoiesis and platelet function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • receptor tyrosine kinases (RTK), which is composed of three members (TYRO3, AXL and MERTK)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for GAS6 and PROS1
  • interacting with RANBP9
  • upstream regulator of MITF expression (TYRO3 induces MITF-M expression in a SOX10-dependent manner in melanoma cells)
  • TULP1 interacts with TYRO3, AXL and MERTK of the TAM receptor tyrosine kinase subfamily, whereas tubby binds only to MERTK
  • cell & other
    REGULATION
    activated by GAS6 and PROS1
    Other regulated by AP-1 in oncogenic activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly elevated in primary melanoma tissue samples and melanoma cell lines and correlates with MITF-M mRNA levels
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    may serve as a target for the development of therapeutic agents for melanoma
    cancerendocrinethyroid
    TYRO3/AXL-GAS6 autocrine circuit sustains the malignant features of thyroid cancer cells and targeting the circuit could offer a novel therapeutic approach in this cancer
    ANIMAL & CELL MODELS