basic FUNCTION
| important modulator of the urokinase-directed vascular smooth muscle cell functional behaviour at the place of injury |
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mediating the activation of STAT proteins |
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involved in signal transduction of cytokine receptors |
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specifically interacts with the proapoptotic protein SIVA1 via its N-terminus region and augments the apoptotic effects induced by SIVA1 through the TYK2-SIVA1 interaction independently of the phosphorylation of SIVA1 by TYK2 |
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role of TYK2 in suppressing the growth and metastasis of breast cancer |
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mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis |
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essential for proper signaling in immune responses and development |
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protein kinase involved in interleukin 12 (IL12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc) |
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participates in signaling through cytokine receptors involved in immune responses and inflammation |