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FLASH GENE
Symbol TXNRD3 contributors: npt - updated : 09-02-2006
HGNC name thioredoxin reductase 3
HGNC id 20667
Location 3p13-q13.33      Physical location : 126.325.894 - 126.373.967
Synonym name
  • thioredoxin reductase TR2
  • thioredoxin glutathione reductase
  • thioredoxin reductase 2
  • Synonym symbol(s) TR2, TRXR3, TGR
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FAD-binding domain
  • a NADPH-binding domain
  • conjugated FlavoP
    HOMOLOGY
    interspecies homolog to rattus LOC297437
    ortholog to murine Txnrd3
    ortholog to dog LOC484619
    Homologene
    FAMILY
  • pyridine nucleotide-disulfide oxidoreductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting on NADH or NADPH as acceptor
  • may have an essential role in redox-regulated cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • FAD
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS