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FLASH GENE
Symbol TXNRD2 contributors: - updated : 03-05-2004
HGNC name thioredoxin reductase 2
HGNC id 18155
Location 22q11.21      Physical location : 19.863.039 - 19.929.359
Synonym name
  • thioredexin reductase beta
  • selenoprotein Z
  • Synonym symbol(s) TRXR2, TR, TR3, SELZ, TR-BETA
    DNA
    TYPE functioning gene
    STRUCTURE 66.00 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2180 - 524 - Kim et al (03)
    precursor, containing a mitochondrial leader peptide, and is located in the mitochondria
    - - 2042 - 428 - Kim et al (03)
    shorter isoform lacking the mitochondrial leader peptide
    - - 2025 - 494 - Kim et al (03)
    shorter isoform lacking the mitochondrial leader peptide (distinct to isoform 2)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    Reproductivefemale systemuterus   
     male systemprostate   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a mitochondrial leading sequence (MLS)
  • selenocysteine residue at the C terminus, conserved active site CVNVGC, and the FAD-binding and NADPH binding domain
  • mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to TRXR1
    Homologene
    FAMILY family of pyridine nucleotide-disulfide oxidoreductases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • thioredoxin reductase activity
  • participates in the regulation of protein tyrosine phosphorylation and cell growth
  • play essential roles in cell survival and mitochondria-mediated apoptosis
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS