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FLASH GENE

Symbol

TXNDC5

contributors: mct - updated : 15-03-2018

HGNC name	thioredoxin domain containing 5
HGNC id	21073

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p24.3      Physical location : 7.881.753 - 7.911.041
Synonym name	endothelial protein disulphide isomerase
	thioredoxin-like protein p46
	endoplasmic reticulum resident protein 46
Synonym symbol(s)	ERP46, UNQ364, EndoPDI, MGC3178, FLJ21353, FLJ90810

DNA

TYPE	functioning gene
STRUCTURE	29.56 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

can be cotranscribed with the upstream gene MUTED

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030810 10 - 3231 NP_110437 47 432 - 2003 12963716 variant 2 - - 3047 isoform 2 - 389 - 2003 12963716 resulting of the cotranscription with the upstream gene MUTED NM_001145549 10 - 3195 NP_001139021 - 324 - 2003 12963716

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas islet of Langerhans     highly Homo sapiens Lymphoid/Immune lymph node       highly   spleen         Nervous brain         Reproductive male system testis       Respiratory lung         Urinary kidney         Visual eye

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Digestive hepatocyte Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	N-terminal two thioredoxin (Trx) domains with positively charged patches near their peptide-binding site
	C-terminal Trx are linked by unusually long loops and arranged extendedly, forming an opened V-shape

HOMOLOGY

interspecies	ortholog to murine Txndc5
	homolog to rattus LOC306869

Homologene

FAMILY	protein disulfide isomerase family
	thioredoxin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,lysosome
text	present in the ER and the plasma membrane (PM)

basic FUNCTION	isomerase activity that may have a role to protect hypoxic cells from apoptosis
	may be an important component in the phenomenon of "glucose toxicity" involved in insulin production at the posttranslational level
	is the first ADIPOR1-specific interacting protein and suggest a role for TXNDC5 in adiponectin receptor biology and adiponectin signalling
	potential role of TXNDC5 in palmitic acid (PA)-induced cell apoptosis
	plays a protective role in PA-induced cell apoptosis by decreasing the ER stress response
	may function as a survival factor for nitrosative stress
	TXNDC5 performs an essential function in Clear cell renal cell carcinoma (ccRCC) pathogenesis

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts specifically with ADIPOR1, providing evidence that TXNDC5 modulates adiponectin signalling
	TXNDC5 is involved in insulin production as well as in adiponectin signaling and interacts specifically with the redox-regulatory endoplasmic reticulum proteins ERO1A and PRDX4
	hyperoxidized PRDX2 interacts with the protein disulfide- isomerase TXNDC5
	TXNDC5, an ER-resident oxidoreductase, associates stably with EDEM3
	triggers the mannose-trimming activity of EDEM3

cell & other

REGULATION

induced by

hypoxia

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in tumors of the cervix, uterus, stomach and lung constitutional       loss of function in fetal growth restriction

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can serve as a novel prognostic marker of Clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed diabete type 2   might be a novel target for anti-diabetic drugs cancer urinary   potential therapeutic target in renal cell carcinoma

ANIMAL & CELL MODELS