Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TXNDC2 contributors: mct - updated : 14-11-2015
HGNC name thioredoxin domain containing 2 (spermatozoa)
HGNC id 16470
Location 18p11.22      Physical location : 9.885.722 - 9.888.150
Genatlas name spermatid-specific thioredoxin-1
Synonym name sperm-specific thioredoxin
Synonym symbol(s) SPTRX-2, SPTRX, SPTRX1
DNA
TYPE functioning gene
STRUCTURE 2.43 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2175 - 553 - 2002 12149401
2 - 1972 - 485 - 2002 12149401
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal domain consisting of 23 highly conserved repetitions of a 15 residue motif
  • a C terminal domain typical of thioredoxins
  • HOMOLOGY
    Homologene
    FAMILY thioredoxin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • reducing insulin disulfide bonds in the presence of NADPH and thioredoxin reductase
  • important factor in regulating critical steps of spermiogenesis
  • may be governing the stabilization (by disulfide cross-linking) of the different structures in the developing tail of spermatids and spermatozoa
  • TXNDC2 and NME8, retain association with the spermatozoa after spermiation and potentially play an important role in regulating the redox status of the mature gamete
  • sperm-specific thioredoxins, TXNDC2 and NME8, are critically important in protecting these cells against the increases in oxidative stress associated with paternal age
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component multimeric structure in native conditions
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS