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FLASH GENE
Symbol TXNDC17 contributors: mct - updated : 11-06-2021
HGNC name thioredoxin domain containing 17
HGNC id 28218
Location 17p13.1      Physical location : 6.544.221 - 6.547.860
Synonym name
  • thioredoxin-like 5
  • thioredoxin (Trx)-related protein, 14 kDa
  • protein 42-9-9
  • testicular tissue protein Li 214
  • Synonym symbol(s) TRP14, MGC14353, TXNL5
    DNA
    TYPE functioning gene
    STRUCTURE 3.48 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1917 13 123 - 2014 24778250
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx   
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two active site Cys residues in its WCPDC motif, which is comparable to the WCGPC motif of thioredoxin (Trx)
  • HOMOLOGY
    Homologene
    FAMILY
  • thioredoxin family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • disulfide reductase modulating TNF-alpha signaling pathways
  • oxidoreductase activities of TXNDC17 complement those of TXN and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols
  • TXNDC17 is likely a member of the thioredoxin system dedicated to the control of cellular redox signalling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TXN
  • DYNLL1 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK, and TXNDC17contributes to this inhibitory activity by maintaining DYNLL1 in a reduced state
  • inhibits the TNF-induced NFKB1 activation to a greater extent than TXN
  • DYNLL1 was identified as a new target of disulfide reductase activity of TXNDC17, and DYNLL1 was shown to bind IkappaBalpha in a redox-dependent manner, thereby preventing its phosphorylation by IKBKB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS