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FLASH GENE
Symbol TXNDC11 contributors: - updated : 13-09-2006
HGNC name thioredoxin domain containing 11
HGNC id 28030
Location 16p13.13      Physical location : 11.772.942 - 11.836.648
Synonym name EF-hand binding protein 1
Synonym symbol(s) EFP1
DNA
TYPE functioning gene
STRUCTURE 63.00 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 mouthtongue  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two thioredoxin domains
HOMOLOGY
Homologene
FAMILY thioredoxin-related protein family
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • may act as a redox regulator involved in DUOX proteins folding
  • could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the cytoplasmic part of DUOX1 and DUOX2
  • interacts with TPO and CYBA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS