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FLASH GENE

Symbol

TXNDC11

contributors: - updated : 13-09-2006

HGNC name	thioredoxin domain containing 11
HGNC id	28030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.13      Physical location : 11.772.942 - 11.836.648
Synonym name	EF-hand binding protein 1
Synonym symbol(s)	EFP1

DNA

TYPE	functioning gene
STRUCTURE	63.00 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   mouth tongue     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two thioredoxin domains

HOMOLOGY

Homologene

FAMILY

thioredoxin-related protein family

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	may act as a redox regulator involved in DUOX proteins folding
	could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with the cytoplasmic part of DUOX1 and DUOX2
	interacts with TPO and CYBA

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS