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FLASH GENE
Symbol TXLNG contributors: mct - updated : 22-12-2012
HGNC name taxilin gamma
HGNC id 18578
Location Xp22.2      Physical location : 16.804.554 - 16.862.640
Synonym name
  • lipopolysaccharide specific response 5 protein
  • factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription
  • chromosome X open reading frame 15
  • gamma-taxilin
  • Synonym symbol(s) FIAT, FLJ11209, LSR5, CXorf15, ELRG
    DNA
    TYPE functioning gene
    STRUCTURE 58.09 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - AMELX - TMSB4X - OFD1 OFD1 - CXorf15 - ZFX - cen
    Authors Skaletsky
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4418 - 528 - 2004 15184072
    8 - 4022 - 396 - 2004 15184072
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an iq domain
  • lacking a basic DNA-binding domain but containing three leucine zippers
  • a myosin head-like domain
  • a rodlike tail sequence highly repetitive, showing cycles of a 28-AA repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • may be playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
  • regulating bone mass accrual and acting as a novel transcriptional regulator of osteoblastic function
  • its inhibition of expression increases ATF4 activity and confirm the important role of TXLNG in osteoblast function
  • inhibits transcriptional activation by a FOSL1/JUN heterodimer without affecting transcription mediated by a JUN homodimer
  • can both modulate early osteoblast activity by interacting with ATF4 and regulate later osteoblast function through inhibition of FOSL1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATF4 (to inhibit binding of ATF4 to DNA and block ATF4-mediated transcription of the osteocalcin gene)
  • could also potentially interact with additional basic domain-leucine zipper transcriptional regulators of osteoblast activity, such as FOSL1 (interaction is mediated through the second leucine zipper of TXLNG)
  • functional interaction between ATF4, TXLNG, and NACA, three proteins that have been previously shown to associate using various protein-protein interaction assays
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS