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FLASH GENE
Symbol TXK contributors: mct - updated : 06-04-2013
HGNC name TXK tyrosine kinase
HGNC id 12434
Location 4p11      Physical location : 48.068.411 - 48.136.273
Synonym name
  • PTK4 protein tyrosine kinase 4
  • resting lymphocyte kinase
  • Synonym symbol(s) RLK, TKL, BTKL, PTK4, PSCTK5
    EC.number 2.7.10.2, 2.7.1.112
    DNA
    TYPE functioning gene
    STRUCTURE 67.86 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    KCTD8 4p13 potassium channel tetramerisation domain containing 8 FLJ39576 4p13 hypothetical protein FLJ39576 FLJ13220 4p13 hypothetical protein FLJ13220 GNPDA2 4p13 glucosamine-6-phosphate deaminase 2 LOC391648 4 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 GABRG1 4p14-q21.1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 GABRA2 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 2 LOC256000 4p13 similar to ras-related C3 botulinum toxin substrate 1 isoform Rac1; rho family, small GTP binding protein Rac1 COX7B2 4p13 cytochrome c oxidase subunit VIIb2 GABRA4 4p14-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRB1 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, beta 1 FLJ20502 4p12 hypothetical protein FLJ20502 ATP10D 4p13-q13.1 ATPase, Class V, type 10D CRN 4p13-p12 corin HOZFP 4p12 ovarian zinc finger protein CNGA1 4p14-q13 cyclic nucleotide gated channel alpha 1 LOC152519 4p12 hypothetical protein LOC152519 TXK 4p12 TXK tyrosine kinase TEC 4p12 tec protein tyrosine kinase KIAA1458 4p12 KIAA1458 protein SLC10A4 4p12 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 ZAR1 4p11 zygote arrest 1 KIAA0826 4p12 KIAA0826 protein OCIA 4q11 KIAA0826 protein MGC45416 4p12 hypothetical protein MGC45416 FLJ21511 4p12 hypothetical protein FLJ21511 LOC391649 4 similar to SNAG1 LOC391650 4 similar to SNAG1 LOC391651 4 similar to SNAG1 LOC391652 4 similar to SNAG1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2714 - 527 - 1999 10213685
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
     thymus   highly Homo sapiensAdult
    Reproductivefemale systemplacenta  highly
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell Homo sapiensAdult
    cell lineage some myeloid cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH2 domain signature
  • a SH3 domain signature
  • a Tyrosine protein kinase domain
  • HOMOLOGY
    interspecies homolog to murine Txk
    homolog to Drosophila Btk29a
    homolog to C.elegans F49b2.5 and T21g5.1
    Homologene
    FAMILY Tyr protein kinase family, TEC subfamily
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • non receptor tyrosine kinase, fuctioning as a TH1L cell-specific transcription factor and regulating IFN-gamma gene transcription
  • critical role for ITK and TXK in conventional CD8(+) T cell development in the thymus
  • ITK and TXK are required for efficient positive selection of conventional CD4+ and CD8+ T cells in the thymus
  • ITK and TXK provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of NKT cells
  • is not a specific regulator of Th1 responses, but with ITK, exert potentially their effects on Th cell differentiation/function at the level of expression
  • important role for ITK and TXK in the development of conventional as opposed to innate CD4(+) and CD8(+) T cells
  • play critical roles in helping shape immune responses via their effects on the differentiation and function of distinct cytokine-producing, effector T-cell populations
  • TXK plays an overlapping role with ITK in iNKT (Invariant NKT) cell development and function but ITK also has a unique function in the survival of iNKT cells, likely via a TP53-dependent pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • ANKRD54 is the first protein identified that specifically influences the nucleocytoplasmic shuttling of BTK and TXK and belongs to a rare group of known proteins carrying out this activity in a CRM1-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributing to excessive TH1L cytokine production by T lymphocytes in patients with Behcet's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    knockout mice (Schaeffer,1999)