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FLASH GENE
Symbol TWISTNB contributors: - updated : 09-02-2007
HGNC name TWIST neighbor
HGNC id 18027
Corresponding disease
DEL7P21 chromosome 7p distal deletion, including TWIST1
Location 7p21      Physical location : 19.735.084 - 19.748.660
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked N status provisional
Map cen - D7S654 - TWISTNB - D7S503 - D7S2559 - D7S2495 - FERD3L - TWIST1 - HDAC9 - D7S2532 - D7S638 - SNX13 - D7S488 - D7S507 - qter
Authors Kosan (02)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrineadrenal gland    
Reproductivefemale systemovary   
 female systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in lung, liver, and kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two potential nuclear localization signals in the C terminus
HOMOLOGY
interspecies ortholog to murine Twistnb
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION DNA-directed RNA polymerase activity
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA binding
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) DEL7P21
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS