Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TWF2 contributors: mlc - updated : 24-11-2007
HGNC name twinfilin, actin-binding protein, homolog 2 (Drosophila)
HGNC id 9621
Location 3p21.1      Physical location : 52.262.626 - 52.273.183
Synonym name
  • PTK9L protein tyrosine kinase 9-like (A6-related protein)
  • A6-related protein
  • Synonym symbol(s) A6RP, PTK9L, A6r, MSTP011
    DNA
    TYPE like-sequence
    STRUCTURE 12.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1659 - 349 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunetonsils   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an actin-binding site
  • an ATP-binding site
  • two ADF/cofilin-like domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals
  • playing a role in growing neurites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction with the catalytic domain of protein kinase C-zeta
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS