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FLASH GENE
Symbol TWF1 contributors: /np - updated : 16-07-2004
HGNC name twinfilin, actin-binding protein, homolog 1 (Drosophila)
HGNC id 9620
Location 12q12      Physical location : 44.187.527 - 44.200.178
Synonym name
  • twinfilin 1
  • A6 protein tyrosine kinase
  • protein tyrosine kinase 9
  • PTK9 protein tyrosine kinase 9
  • Synonym symbol(s) A6, MGC23788, MGC41876, PTK9
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3065 - 384 - Vartiainen
    - splicing 3455 - 252 - Vartiainen
    a shorter N-terminus due to translation intiation at a downstream start codon
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain   lowly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    Urinarybladder   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two actin-depolymerisation factor/cofilin-like domains
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Ptk9
    homolog to rattus LOC315265
    Homologene
    FAMILY actin-binding protein ADF family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • may be an actin monomer-binding protein, preventing the assembly of monomers into filaments
  • regulating the cytoskeletal dynamics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component form a1 : 1 complex with ADP-actin-monomers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with capping protein
  • cell & other
    REGULATION
    Other phosphorylated on ser/thr residues
    small GTPase RAC1 and CDC42 regulate its localization
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS