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FLASH GENE
Symbol TWF1 contributors: mct - updated : 05-04-2023
HGNC name twinfilin, actin-binding protein, homolog 1 (Drosophila)
HGNC id 9620
Location 12q12      Physical location : 44.187.527 - 44.200.178
Synonym name
  • twinfilin 1
  • A6 protein tyrosine kinase
  • protein tyrosine kinase 9
  • PTK9 protein tyrosine kinase 9
  • Synonym symbol(s) A6, MGC23788, MGC41876, PTK9
    DNA
    TYPE functioning gene
    STRUCTURE 12.59 kb     9 Exon(s)
    motif Viral sequence   gene env
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3008 - 357 - 2003 12807912
    9 splicing 2987 - 350 - 2003 12807912
    a shorter N-terminus due to translation intiation at a downstream start codon
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain   lowly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    Urinarybladder   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two actin-depolymerisation factor/cofilin-like domains
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Ptk9
    homolog to rattus LOC315265
    Homologene
    FAMILY actin-binding protein ADF family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    basic FUNCTION
  • may be an actin monomer-binding protein, preventing the assembly of monomers into filaments
  • regulating the cytoskeletal dynamics
  • regulates cytoskeletal dynamics by capping actin filament barbed-ends
  • implicated in cell motility, invasion and migration
  • is likely an important mediator of both cholangiocyte adaptation to aging processes and response to injury
  • controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation
  • known to regulate actin filament assembly by sequestering actin monomer and capping barbed ends
  • essential role of TWF1 in the myogenic differentiation of progenitor cells via modulation of F-actin and YAP1
  • regulates actin dynamics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component form a1 : 1 complex with ADP-actin-monomers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with capping protein
  • cell & other
    REGULATION
    Other phosphorylated on ser/thr residues
    small GTPase RAC1 and CDC42 regulate its localization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Lung adenocarcinoma (LUAD) as well as lung squamous cell carcinoma (LUSC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of TWF1 to be independent prognostic indicator involved in overall survival of Lung adenocarcinoma (LUAD)
  • Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathy 
    potential therapeutic target for muscle wasting and myopathies
    cancerlung 
    suitable therapeutic target against LUAD
    ANIMAL & CELL MODELS