motifs/domains
| N-terminal portion, which lacks nucleotidyltransferase capabilities, is biologically active and mediates a previously unrecognized role in facilitating cell proliferation |
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a CCHH zinc finger, which typically interacts with |
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RNA or DNA |
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a C2H2-type zinc finger domain |
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two poly(A) polymerase/2'5'-oligoadenylate synthetase |
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(PAP/25A)-associated domains, common in RNA-modifying enzymes7 |
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three CCHC zinc knuckles |
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a pol betta domain, which usually mediates nucleotidyltransferase activity |
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RNA-interacting motifs |
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two nucleotidyltransferase domains |
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C-terminal region is an active uridyltransferase enzyme capable of adding free uridine residues to RNA molecules |
basic FUNCTION
| nucleotidyltransferase activity |
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may play a role in sister chromatid cohesion |
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implicated in signaling pathways involved in cytokine expression |
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a ribonucleotidyltransferase with a preference for |
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uridine, essential for maintaining the poly(A) tail length and stability of transcripts for interleukin 6 |
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responsible for the untemplated uridylation of mature miRNA |
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role for ZCCHC11-catalyzed pre-let-7 uridylation in the control of miRNA biogenesis |
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is the terminal U-transferase responsible for targeting human histone mRNAs for degradation following inhibition or completion of DNA replication |
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MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner |
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promotes the transition from G1 to S phase of the cell cycle |
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may play critical roles in cell proliferation driven by its nucleotidyltransferase activity |
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contributes to the cell cycle by facilitating the expression of multiple cyclins and cyclin-dependent kinases to enhance steps of G1 progression both upstream and downstream of Rb phosphorylation |
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ZCCHC11 and ZCCHC6 redundantly control let-7 biogenesis in embryonic stem cells |
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ZCCHC6, ZCCHC11, and PAPD4 are the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation |
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implicated in microRNA (miRNA) regulation, and TUT4-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF1 expression and enhancing postnatal growth and survival |