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FLASH GENE
Symbol TUT4 contributors: shn/mct/pgu - updated : 03-07-2013
HGNC name terminal uridylyl transferase 4
HGNC id 28981
Location 1p32.3      Physical location : -
Synonym name
  • KIAA0191 protein
  • PAP associated domain containing 3
  • TUTase 43
  • zinc finger, CCHC domain containing 11
  • Synonym symbol(s) KIAA0191, PAPD3, ZCCHC11, TENT3A
    EC.number 2.7.7.52
    DNA
    TYPE functioning gene
    STRUCTURE 129.80 kb     30 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S319 - D1S231 - ZCCHC11 - D1S509 - D1S2661 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 5845 185 1645 thymus, spleen, testes and lung - lung alveolar epithelial cell lines (A549 and MLE‑15) 2009 19701194
    30 splicing 5842 185 1644 thymus, spleen, testes and lung - lung alveolar epithelial cell lines (A549 and MLE‑15) 2009 19701194
    30 splicing 5830 184 1640 thymus, spleen, testes and lung - lung alveolar epithelial cell lines (A549 and MLE‑15) 2009 19701194
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Gustatory (taste)tongue    
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal portion, which lacks nucleotidyltransferase capabilities, is biologically active and mediates a previously unrecognized role in facilitating cell proliferation
  • a CCHH zinc finger, which typically interacts with
  • RNA or DNA
  • a C2H2-type zinc finger domain
  • two poly(A) polymerase/2'5'-oligoadenylate synthetase
  • (PAP/25A)-associated domains, common in RNA-modifying enzymes7
  • three CCHC zinc knuckles
  • a pol betta domain, which usually mediates nucleotidyltransferase activity
  • RNA-interacting motifs
  • two nucleotidyltransferase domains
  • C-terminal region is an active uridyltransferase enzyme capable of adding free uridine residues to RNA molecules
  • HOMOLOGY
    interspecies ortholog to Zcchc11, Mus musculus
    ortholog to Zcchc11, Rattus norvegicus
    ortholog to ZCCHC11, Pan troglodytes
    Homologene
    FAMILY
  • DNA polymerase betta-like nucleotidyltransferase superfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • nucleotidyltransferase activity
  • may play a role in sister chromatid cohesion
  • implicated in signaling pathways involved in cytokine expression
  • a ribonucleotidyltransferase with a preference for
  • uridine, essential for maintaining the poly(A) tail length and stability of transcripts for interleukin 6
  • responsible for the untemplated uridylation of mature miRNA
  • role for ZCCHC11-catalyzed pre-let-7 uridylation in the control of miRNA biogenesis
  • is the terminal U-transferase responsible for targeting human histone mRNAs for degradation following inhibition or completion of DNA replication
  • MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner
  • promotes the transition from G1 to S phase of the cell cycle
  • may play critical roles in cell proliferation driven by its nucleotidyltransferase activity
  • contributes to the cell cycle by facilitating the expression of multiple cyclins and cyclin-dependent kinases to enhance steps of G1 progression both upstream and downstream of Rb phosphorylation
  • ZCCHC11 and ZCCHC6 redundantly control let-7 biogenesis in embryonic stem cells
  • ZCCHC6, ZCCHC11, and PAPD4 are the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation
  • implicated in microRNA (miRNA) regulation, and TUT4-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF1 expression and enhancing postnatal growth and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the miRNA biogenesis pathway with ZCCHC6, PAPD4
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • TRAF-interacting protein with forkhead-associated domain, TIFA
  • interaction with LIN28A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Zcchc11 deficiency had no impact on embryogenesis or fetal development, but it significantly decreased survival and growth immediately following birth, indicating a role in early postnatal fitness