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FLASH GENE
Symbol TUT1 contributors: mct - updated : 04-07-2013
HGNC name terminal uridylyl transferase 1, U6 snRNA-specific
HGNC id 26184
Location 11q12.3      Physical location : 62.342.516 - 62.359.109
Synonym name
  • PAP-associated domain-containing 2
  • RNA binding motif protein 21
  • RNA uridylyltransferase
  • speckle targeted PIP5K1A-regulated poly(A) polymerase
  • star-PAP
  • Synonym symbol(s) PAPD2, RBM21, STARPAP, TUTase
    EC.number 2.7.7.19 / 2.7.7.52
    DNA
    TYPE functioning gene
    STRUCTURE 16.59 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2844 - 912 - 2010 21102410
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • poly (A) polymerase (PAP) that is putatively required for 3prime-end cleavage and polyadenylation of a select set of pre-messenger RNAs (mRNAs), including heme oxygenase (HO-1) mRNA
  • MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner
  • TUT1-control of BIK expression and apoptosis is regulated by nuclear PIP5K1A and PRKCD signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex therefore represents a location where multiple signaling pathways converge to regulate the expression of specific mRNAs
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the RNA, recruits the CPSF complex to the 3prime-end of pre-mRNA and then defines cleavage by CPSF3 and subsequent polyadenylation of its target mRNAs
  • LARP7 interacts with a poly(A) polymerase TUT1 to maintain LIN28A mRNA stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS