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FLASH GENE
Symbol TUSC1 contributors: npt - updated : 11-04-2006
HGNC name tumor suppressor candidate 1
HGNC id 31010
Location 9pter-p23      Physical location : 25.676.393 - 25.678.856
Synonym name
  • tumor suppressor gene(s), chromosome 9
  • TUSC1 protein
  • Synonym symbol(s) TSG9E, TSG9, MGC131751
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    motif Viral sequence   gene env
    text structure intronless
    MAPPING cloned Y linked N status provisional
    Map pter - D9S54 - D9S199 - D9S156 - [D9S157 - [[D9S162 ]] - IFNA1 - D9S171 - D9S126 ] - D9S169 - D9S104 - cen
    Authors Neville (95)
    Text [ ] : minimal critical region, [[ ]] : breast carcinomas
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2477 23 212 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • tumor suppressor gene(s), may playing a role in lung tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in breast cancer and in meningioma with poor prognostic
    tumoral   LOH    
    in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS