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FLASH GENE
Symbol TUBGCP5 contributors: mct - updated : 13-10-2016
HGNC name tubulin, gamma complex associated protein 5
HGNC id 18600
Location 15q11.2      Physical location : 22.833.394 - 22.873.889
Synonym name gamma-tubulin complex component 5
Synonym symbol(s) GCP5, KIAA1899
DNA
TYPE functioning gene
STRUCTURE 40.49 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   cAMP
MAPPING cloned Y linked N status provisional
Physical map
LOC390535 15 similar to golgin-67 isoform c LOC390536 15 hypothetical gene supported by NM_144726 LOC388070 15 hypothetical gene supported by NM_002577 LOC390537 15 similar to CDC42-binding protein kinase alpha isoform A; ser-thr protein kinase related to the myotonic dystrophy protein kinase; ser-thr protein kinase PK428; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; CD LOC388071 15 hypothetical gene supported by AL834140; NM_001338 LOC339010 15q11.2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC283804 15q11.2 similar to testicular Metalloprotease-like, Disintegrin-like, Cysteine-rich protein IVb LOC388072 15 similar to breast cancer anti-estrogen resistance 1; Crk-associated substrate p130Cas; Crk-associated substrate LOC388073 15 hypothetical gene supported by AK056084; NM_152518 LOC388074 15 similar to Ribosome biogenesis protein BMS1 homolog LOC388075 15 similar to Ribosome biogenesis protein BMS1 homolog OR4H6P 15p12 olfactory receptor, family 4, subfamily H, member 6 pseudogene LOC390538 15 similar to Olfactory receptor 4M2 LOC390539 15 similar to seven transmembrane helix receptor LOC388076 15 similar to 40S ribosomal protein S8 LOC388077 15 similar to immunoglobulin heavy chain variable region LOC390540 15 similar to salivary proline-rich protein LOC388078 15 similar to FLJ27099 protein LOC388079 15 similar to ZCCHC2 protein LOC390541 15 similar to arginine-glutamic acid dipeptide (RE) repeats; atrophin 1-like; arginine glutamic acid dipeptide RE repeats LOC390542 15 similar to CDNA sequence BC005632 LOC390543 15 similar to ATP-binding cassette, sub-family B, member 10, mitochondrial precursor (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2) LOC388080 15 similar to hypothetical protein LOC283767 15q11.2 hypothetical gene supported by AK093450 LOC390544 15 similar to engulfment and cell motility 2; ced-12 homolog 2; PH domain protein CED12A TUBGCP5 15q11.1 tubulin, gamma complex associated protein 5 CYFIP1 15q11 cytoplasmic FMR1 interacting protein 1 NIPA2 15q11.2 non-imprinted in Prader-Willi/Angelman syndrome 2 SPG6 15q11-q13 spastic paraplegia 6 (autosomal dominant) LOC339003 15q11.2 similar to HP95 LOC388081 15 LOC388081 LOC339005 15q11.2 hypothetical protein LOC339005 FLJ35785 15q11.2 hypothetical protein FLJ35785 LOC388082 15 hypothetical gene supported by AB002391 LOC390545 15 similar to hypothetical protein FLJ36144 LOC390546 15 similar to golgin-67 isoform c LOC388083 15 similar to hypothetical protein FLJ31951 LOC390547 15 similar to neuronal nonacetlycholine binding subunit LOC390548 15 similar to hypothetical protein FLJ36144 LOC388084 15 similar to FLJ40113 protein LOC388085 15 similar to Golgi autoantigen, golgin subfamily a, 2; golgin-95; Golgi matrix protein GM130; SY11 protein LOC390549 15 similar to hect domain and RLD 2 FLJ36144 15q11.2 hypothetical protein FLJ36144 MKRN3 15q11-q12 makorin, ring finger protein, 3 MAGEL2 15q11.2-q12 MAGE-like 2 NDN 15q11.2-q12 necdin homolog (mouse)
regionally located . located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3934 118.3 1024 - 2001 11694571
22 - 3442 118.3 1024 - 2001 11694571
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
Text expressed in fetal heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic motif is present in the N-terminus
  • HOMOLOGY
    interspecies ortholog to murine Tubgcp5
    Homologene
    FAMILY GCP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • necessary for microtublule nucleation at the centrosome
  • required for the formation or stability of gammaTuRC (gamma-tubulin ring complex) and the recruitment of gamma-tubulin to the spindle poles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of GSK3B in the proper formation of the mitotic spindles through an interaction with GCP5 (GSK3B regulates the localization of gammaTuRC, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles)
  • recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in congenital heart disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS