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FLASH GENE
Symbol TUBE1 contributors: - updated : 15-09-2004
HGNC name tubulin, epsilon 1
HGNC id 20775
Location 6q12      Physical location : 112.391.860 - 112.408.751
Synonym symbol(s) dJ142L7.2, FLJ22589, TUBE
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391959 6 similar to calponin 2; Calonin 2 AMD1 6q21-q22 adenosylmethionine decarboxylase 1 LOC221269 6q22.1 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) C6orf51 6q21 chromosome 6 open reading frame 51 BXDC1 6q22.1 brix domain containing 1 LOC221270 6q22.1 similar to glutathione transferase M2 SLC16A10 6q21-q22 solute carrier family 16 (monocarboxylic acid transporters), member 10 KIAA1919 6q22 KIAA1919 REV3L 6q21 REV3-like, catalytic subunit of DNA polymerase zeta (yeast) LOC51212 6q22.1 diferentiation-related protein dif13 C6orf4 6q21 chromosome 6 open reading frame 4 FYN 6q21 FYN oncogene related to SRC, FGR, YES WISP3 6q22-q23 WNT1 inducible signaling pathway protein 3 TUBE1 6q12 tubulin, epsilon 1 LAMA4 6q21 laminin, alpha 4 LOC345882 6q22.1 similar to Pin2-interacting protein X1 (TRF1-interacting protein 1) (Liver-related putative tumor suppressor) (67-11-3 protein) LOC221278 6q22.1 similar to ret finger protein-like 1 LOC391960 6 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC345884 6q22.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC391961 6 similar to fem-1 homolog a (C.elegans) LOC389424 6 similar to Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) LOC391962 6 similar to Cytokine inducible SH2-containing protein 5 (Suppressor of cytokine signaling 5) (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines osteogenic sarcoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a GTP binding domain
HOMOLOGY
interspecies homolog to murine Tube1
homolog to rattus LOC361856
Homologene
FAMILY tubulin family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text peri-contriolar material localization in a cell cycle dependent-manner, first associated with the older centrosome of a newly duplicated pair and then associated with both
basic FUNCTION
  • structural constituent of the cytoskeleton involved in microtubule polymerization
  • may have a GTPase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS