Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TUBB contributors: mct - updated : 06-01-2016
HGNC name tubulin, beta
HGNC id 20778
Corresponding disease
CDCBM6 cortical dysplasia, complex, with other brain malformations 6
CSCKT1 circumferential skin creases Kunze type syndrome 1
Location 6p21.33      Physical location : 1.981.087 - 30.693.193
Synonym name
  • beta 5-tubulin
  • tubulin beta-1 chain
  • beta-4 tubulin
  • beta Ib tubulin
  • Synonym symbol(s) TUBB1, TUBB5, M40, OK/SW-cl.56, MGC117247, MGC16435, CDCBM6
    DNA
    TYPE functioning gene
    STRUCTURE 5.23 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see MHC1
    Physical map
    LOC285770 6p25.2 similar to FLJ00254 protein C6orf195 6p25.2 chromosome 6 open reading frame 195 LOC340156 6p25.2 hypothetical protein LOC340156 WRNIP1 6p24.3 Werner helicase interacting protein 1 SERPINB1 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 SERPINB9 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 SERPINB6 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 NQO2 6p25-p24.3 NAD(P)H dehydrogenase, quinone 2 LOC391864 6 similar to HIV TAT specific factor 1; cofactor required for Tat activation of HIV-1 transcription LOC221754 6p25.2 similar to dJ40E16.3 (novel gene similar to D. melanogaster CG5327 ) RIPK1 6p25.3-p24.1 receptor (TNFRSF)-interacting serine-threonine kinase 1 BPHL 6p25 biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) TUBB 6p21.3 tubulin, beta polypeptide MGC8685 6p25 tubulin, beta polypeptide paralog LOC389362 6 LOC389362 C6orf85 6p25.2 chromosome 6 open reading frame 85 DKFZP434F011 6p25.2-p25.1 ion transporter protein C6orf145 6p25.1 chromosome 6 open reading frame 145 D6S2654E 6pter DNA segment on chromosome 6(unique) 2654 expressed sequence LOC389363 6 hypothetical gene supported by AF118652; NM_006541 PRPF4B 6p24.2 PRP4 pre-mRNA processing factor 4 homolog B (yeast) C6orf146 6p25.1 chromosome 6 open reading frame 146 PECI 6p24.3 peroxisomal D3,D2-enoyl-CoA isomerase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2772 - 464 - -
    4 - 2688 - 444 - -
    5 - 2082 - 242 - -
    3 - 2556 - 400 - -
    4 - 2675 - 372 - -
    4 - 2574 - 372 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Tubb5 (100 pc)
    homolog to murine Tubb5 (100 pc)
    Homologene
    FAMILY
  • tubulin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • being the major constituent of microtubules
  • is necessary for the proper generation and migration of neurons
  • is essential for neuronal differentiation and dendritic spine formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of alpha and beta chains
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • cations such as calcium
  • GTP
  • protein
  • interaction between TRPV4 and tubulin beta 5 by associating together
  • ADAP2 interaction with TUBB involving the C-terminal region of TUBB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT1 , CDCBM6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS