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FLASH GENE
Symbol TUBA4A contributors: - updated : 31-08-2007
HGNC name tubulin, alpha 4a
HGNC id 12407
Location 2q35      Physical location : 220.115.000 - 220.118.638
Synonym name testis-specific alpha tubulin
Synonym symbol(s) FLJ30169, H2-ALPHA, TUBA1
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two additional related transcripts expressed in every tissue (Dobner)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils   highly
Nervousbrain   highly
Reproductivemale systemtestis  specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to C.elegans tba-2
ortholog to rattus tuba4 (92 pc)
Homologene
FAMILY tubulin superfamily composed of six distinct families
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • major components of microtubules, having a GTPase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer of alpha and beta tubulin
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • binds two moles of GTP, one at an
  • exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain
    protein
  • GRM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS