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FLASH GENE
Symbol TTYH3 contributors: KTN/npt - updated : 05/11/2008
HGNC name tweety homolog 3 (Drosophila)
HGNC id 22222
Location 7p22.2      Physical location : 2.671.602 - 2.704.427
Synonym name tweety 3
Synonym symbol(s) KIAA1691
DNA
TYPE functioning gene
STRUCTURE 32.83 kb     14 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4838 57.4 523 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
 salivary gland   predominantly
Reproductivefemale systemovary  moderately
Skin/Tegumentskin   highly
Urinarykidney   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly in embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • a glutamate and aspartate-rich Ca(2+) bowl-like sequence
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TTYH3 (92 pc)
    homolog to rattus Ttyh3 (94.8 pc)
    homolog to murine Ttyh3 (94.6 pc)
    homolog to chicken TTYH3 (76.8 pc)
    Homologene
    FAMILY
  • tweety family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text multi-pass membrane protein
    basic FUNCTION
  • being a probable large-conductance Ca(2+)-activated chloride channel
  • may play a role in Ca(2+) signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text Cl- transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
  • Ca2+
  • protein
    cell & other
    REGULATION
    Other N-glycosylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS